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Role of 5-HT3 Receptors in the Antidepressant Response
University of Lyon, F-69008, Lyon, France
Laboratory of Neuropharmacology, Faculty of pharmacy, University of Lyon 1, F-69008, Lyon, France
H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark
Lundbeck Research USA, Inc., Paramus, NJ 07652, USA
* Author to whom correspondence should be addressed.
Received: 9 February 2011; in revised form: 20 March 2011 / Accepted: 31 March 2011 / Published: 7 April 2011
Abstract: Serotonin (5-HT)3 receptors are the only ligand-gated ion channel of the 5-HT receptors family. They are present both in the peripheral and central nervous system and are localized in several areas involved in mood regulation (e.g., hippocampus or prefrontal cortex). Moreover, they are involved in regulation of neurotransmitter systems implicated in the pathophysiology of major depression (e.g., dopamine or GABA). Clinical and preclinical studies have suggested that 5-HT3 receptors may be a relevant target in the treatment of affective disorders. 5-HT3 receptor agonists seem to counteract the effects of antidepressants in non-clinical models, whereas 5-HT3 receptor antagonists, such as ondansetron, present antidepressant-like activities. In addition, several antidepressants, such as mirtazapine, also target 5-HT3 receptors. In this review, we will report major advances in the research of 5-HT3 receptor’s roles in neuropsychiatric disorders, with special emphasis on mood and anxiety disorders.
Keywords: 5-HT3 receptors; depression; new therapeutics
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Bétry, C.; Etiévant, A.; Oosterhof, C.; Ebert, B.; Sanchez, C.; Haddjeri, N. Role of 5-HT3 Receptors in the Antidepressant Response. Pharmaceuticals 2011, 4, 603-629.
Bétry C, Etiévant A, Oosterhof C, Ebert B, Sanchez C, Haddjeri N. Role of 5-HT3 Receptors in the Antidepressant Response. Pharmaceuticals. 2011; 4(4):603-629.
Bétry, Cécile; Etiévant, Adeline; Oosterhof, Chris; Ebert, Bjarke; Sanchez, Connie; Haddjeri, Nasser. 2011. "Role of 5-HT3 Receptors in the Antidepressant Response." Pharmaceuticals 4, no. 4: 603-629.