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Pharmaceuticals 2016, 9(2), 21; doi:10.3390/ph9020021

The Post-Ovariectomy Interval Affects the Antidepressant-Like Action of Citalopram Combined with Ethynyl-Estradiol in the Forced Swim Test in Middle Aged Rats

1
Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, INPRFM, Calzada México-Xochimilco 101, Col San Lorenzo Huipulco 14370, Mexico
2
Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados-Sede Sur. IPN, Calzada de los Tenorios 235, Col Granjas Coapa 14330, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Guy Griebel
Received: 31 December 2015 / Revised: 14 April 2016 / Accepted: 18 April 2016 / Published: 3 May 2016
(This article belongs to the Special Issue Antidepressants: Current Progress and Future Prospects)
View Full-Text   |   Download PDF [591 KB, uploaded 3 May 2016]   |  

Abstract

The use of a combined therapy with low doses of estrogens plus antidepressants to treat depression associated to perimenopause could be advantageous. However the use of these combinations is controversial due to several factors, including the time of intervention in relation to menopause onset. This paper analyzes whether time post-OVX influences the antidepressant-like action of a combination of ethynyl-estradiol (EE2) and citalopram (CIT) in the forced swim test (FST). Middle-aged (15 months old) female Wistar rats were ovariectomized and after one or three weeks treated with EE2 (1.25, 2.5 or 5.0 µg/rat, s.c.; −48 h) or CIT (1.25, 2.5, 5.0 or 10 mg/kg, i.p./3 injections in 24 h) and tested in the FST. In a second experiment, after one or three weeks of OVX, rats received a combination of an ineffective dose of EE2 (1.25 µg/rat, s.c., −48 h) plus CIT (2.5 mg/kg, i.p./3 injections in 24 h) and subjected to the FST. Finally, the uteri were removed and weighted to obtain an index of the peripheral effects of EE2 administration. EE2 (2.5 or 5.0 µg/rat) reduced immobility after one but not three weeks of OVX. In contrast, no CIT dose reduced immobility at one or three weeks after OVX. When EE2 (1.25 µg/rat) was combined with CIT (2.5 mg/kg) an antidepressant-like effect was observed at one but not three weeks post-OVX. The weight of the uteri augmented when EE2 was administrated three weeks after OVX. The data suggest that the time post-OVX is a crucial factor that contributes to observe the antidepressant-like effect of EE2 alone or in combination with CIT. View Full-Text
Keywords: ethynyl-estradiol; citalopram; forced swim test; post-OVX interval; perimenopause; antidepressant-like effect ethynyl-estradiol; citalopram; forced swim test; post-OVX interval; perimenopause; antidepressant-like effect
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vega Rivera, N.M.; Gallardo Tenorio, A.; Fernández-Guasti, A.; Estrada Camarena, E. The Post-Ovariectomy Interval Affects the Antidepressant-Like Action of Citalopram Combined with Ethynyl-Estradiol in the Forced Swim Test in Middle Aged Rats. Pharmaceuticals 2016, 9, 21.

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