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• Bini, V
• Tambaro, S
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• Bini, V
• Tambaro, S

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Pharmaceuticals 2010, 3(9), 2799-2820; doi:10.3390/ph3092799

Review

Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis

Marco Bortolato ^1,2,* , Valentina Bini ^2,3  and Simone Tambaro ^1,4

¹ Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033, USA ² Tourette Syndrome Center, University of Cagliari, Italy ³ Department of Neuroscience “Bernard B. Brodie”, University of Cagliari, Italy ⁴ Neuroscience PharmaNess, S.C.A.R.L., Edificio 5, Parco Scientifico e Tecnologico della Sardegna, Località Piscinamanna, Pula, Cagliari, Italy

* Author to whom correspondence should be addressed.

Received: 29 July 2010; in revised form: 23 August 2010 / Accepted: 25 August 2010 / Published: 26 August 2010

(This article belongs to the Special Issue Cannabinoids)

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Abstract: Cogent evidence shows that cannabis plays a variable role on behavioral regulation and the pathophysiology of most psychiatric conditions. Accordingly, cannabis has been alternatively shown to exacerbate or ameliorate mental symptoms, depending on its composition and route of consumption, as well as specific individual and contextual characteristics. The vulnerability to the psychological effects of cannabis is influenced by a complex constellation of genetic and environmental factors. In the present article, we will review the current evidence on the pharmacological, individual and situational factors that have been documented to affect the behavioral and psychiatric effects of cannabinoids.

Keywords: cannabinoids; vulnerability; CB receptors

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