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Pharmaceuticals 2010, 3(5), 1286-1295; doi:10.3390/ph3051286

Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection

Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
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Received: 30 March 2010 / Revised: 12 April 2010 / Accepted: 22 April 2010 / Published: 27 April 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
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Abstract

Cyclooxygenase and lipoxygenase, two important enzymes involved in arachidonic acid metabolism, are major targets of non-steroidal anti-inflammatory drugs (NSAIDs). Recent investigations suggest that arachidonic cascades and their metabolites may be involved in maintaining inner ear functions. The excessive use of aspirin may cause tinnitus in humans and impairment of the outer hair cell functions in experimental animals. On the other hand, NSAIDs reportedly exhibit protective effects against various kinds of inner ear disorder. The present review summarizes the effects of NSAIDs on cochlear pathophysiology. NSAIDs are a useful ameliorative adjunct in the management of inner ear disorders.
Keywords: NSAIDs; cochlea; cyclooxygenase; lipoxygenase NSAIDs; cochlea; cyclooxygenase; lipoxygenase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hoshino, T.; Tabuchi, K.; Hara, A. Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection. Pharmaceuticals 2010, 3, 1286-1295.

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