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Pharmaceuticals 2010, 3(5), 1296-1303; doi:10.3390/ph3051296
Review

The Treatment of Melioidosis

1,2,3
1 Division of Microbiology & Infectious Diseases, PathWest Laboratory Medicine WA, QEII Medical Centre, Nedlands, WA 6009, Australia 2 Microbiology & Immunology, School of Biomedical, Biomolecular and Chemical Sciences, Faculty of Life & Applied Sciences, University of Western Australia, Crawley, WA 6009, Australia 3 School of Pathology and Laboratory Medicine, Faculty of Medicine & Dentistry, University of Western Australia, Crawley, WA 6009, Australia
Received: 19 January 2010 / Revised: 29 March 2010 / Accepted: 20 April 2010 / Published: 27 April 2010
(This article belongs to the Special Issue Tropical Medicine)
View Full-Text   |   Download PDF [102 KB, uploaded 27 April 2010]

Abstract

Melioidosis is a complex bacterial infection, treatment of which combines the urgency of treating rapidly fatal Gram negative septicaemia with the need for eradication of long-term persistent disease in pulmonary, soft tissue, skeletal and other organ systems. Incremental improvements in treatment have been made as a result of multicentre collaboration across the main endemic region of Southeast Asia and northern Australia. There is an emerging consensus on the three main patterns of antimicrobial chemotherapy; initial (Phase 1) treatment, subsequent eradication (Phase 2) therapy and most recently post-exposure (Phase 0) prophylaxis. The combination of agents used, duration of therapy and need for adjunct modalities depends on the type, severity and antimicrobial susceptibility of infection. New antibiotic and adjunct therapies are at an investigational stage but on currently available data are unlikely to make a significant impact on this potentially fatal infection.
Keywords: melioidosis; treatment; antibiotics; adjunct therapy melioidosis; treatment; antibiotics; adjunct therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Inglis, T.J. The Treatment of Melioidosis. Pharmaceuticals 2010, 3, 1296-1303.

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