Next Article in Journal / Special Issue
Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection
Previous Article in Journal
Thrombospondin-1 as a Paradigm for the Development of Antiangiogenic Agents Endowed with Multiple Mechanisms of Action
Previous Article in Special Issue
A Review of Anti-Inflammatory Drug-Induced Gastrointestinal Injury: Focus on Prevention of Small Intestinal Injury
Pharmaceuticals 2010, 3(4), 1279-1285; doi:10.3390/ph3041279
Article

Significant Acute Kidney Injury Due to Non-steroidal Anti-inflammatory Drugs: Inpatient Setting

* , ,  and
Received: 5 February 2010; in revised form: 14 April 2010 / Accepted: 19 April 2010 / Published: 26 April 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
View Full-Text   |   Download PDF [42 KB, updated 29 April 2010; original version uploaded 26 April 2010]
Abstract: In the United States non-steroidal anti-inflammatory drugs (NSAID) are freely available over-the-counter. Because of the adverse effects on the kidneys and the popularity of these drugs, unregulated use of NSAIDs is an under recognized and potentially dangerous problem. Fifteen inpatients, mean age of 15.2 ± 2.3 years (five males, 10 females), were referred to nephrology for acute kidney injury. All patients admitted to taking ibuprofen and six also consumed naproxen. None of the patients had underlying renal diseases at the time of admission. Nine patients had proteinuria and 12 had hematuria (including one with gross hematuria). One patient had nephrotic syndrome but the condition resolved spontaneously without steroids and has remained in remission for four years. Two patients required dialysis. Only one of the dialyzed patients required steroid therapy for recovery of renal function. The mean duration of hospitalization was 7.4 ± 5.5 days. The serum creatinine peaked at 4.09 ± 4.24 (range 1.2-15.3) mg/dL. All patients recovered renal function with normalization of serum creatinine to 0.71 ± 0.15 mg/dL. The estimated GFR (glomerular filtration rate) at peak of renal failure was 38.2 ± 20.5 mL/min but did improve to a baseline of 134 ± 26.2 mL/min (range 89-177, p < 0.01). However, the duration from onset to normalization of serum creatinine was 37 ± 42 days indicating that majority of patients had abnormal renal function for a prolonged period. In conclusion, NSAIDs pose a significant risk of renal failure for significant duration and as an entity may be under recognized.
Keywords: children; pain killers; renal insufficiency; ibuprofen; dialysis; steroid; acute interstitial nephritis; acute renal failure children; pain killers; renal insufficiency; ibuprofen; dialysis; steroid; acute interstitial nephritis; acute renal failure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Dixit, M.; Doan, T.; Kirschner, R.; Dixit, N. Significant Acute Kidney Injury Due to Non-steroidal Anti-inflammatory Drugs: Inpatient Setting. Pharmaceuticals 2010, 3, 1279-1285.

AMA Style

Dixit M, Doan T, Kirschner R, Dixit N. Significant Acute Kidney Injury Due to Non-steroidal Anti-inflammatory Drugs: Inpatient Setting. Pharmaceuticals. 2010; 3(4):1279-1285.

Chicago/Turabian Style

Dixit, Mehul; Doan, Thuy; Kirschner, Rebecca; Dixit, Naznin. 2010. "Significant Acute Kidney Injury Due to Non-steroidal Anti-inflammatory Drugs: Inpatient Setting." Pharmaceuticals 3, no. 4: 1279-1285.


Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert