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Pharmaceuticals 2010, 3(11), 3355-3370; doi:10.3390/ph3113355

Inactivation of Anandamide Signaling: A Continuing Debate

School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
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Received: 25 August 2010 / Revised: 9 October 2010 / Accepted: 25 October 2010 / Published: 28 October 2010
(This article belongs to the Special Issue Cannabinoids)
View Full-Text   |   Download PDF [186 KB, uploaded 28 October 2010]   |  

Abstract

Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system. While it was established that the activity of endocannabinoids are terminated by a two-step process that includes cellular uptake and degradation, there is still a continuing debate about the mechanistic role of these processes in inactivating anandamide signals. View Full-Text
Keywords: endocannabinoid inactivation; anandamide; ethanolamine endocannabinoid inactivation; anandamide; ethanolamine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Khairy, H.; Houssen, W.E. Inactivation of Anandamide Signaling: A Continuing Debate. Pharmaceuticals 2010, 3, 3355-3370.

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