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Pharmaceuticals 2010, 3(11), 3355-3370; doi:10.3390/ph3113355

Review

Inactivation of Anandamide Signaling: A Continuing Debate

Hesham Khairy and Wael E. Houssen*

School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK

* Author to whom correspondence should be addressed.

Received: 25 August 2010; in revised form: 9 October 2010 / Accepted: 25 October 2010 / Published: 28 October 2010

(This article belongs to the Special Issue Cannabinoids)

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Abstract: Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system. While it was established that the activity of endocannabinoids are terminated by a two-step process that includes cellular uptake and degradation, there is still a continuing debate about the mechanistic role of these processes in inactivating anandamide signals.

Keywords: endocannabinoid inactivation; anandamide; ethanolamine

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