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Pharmaceuticals 2010, 3(10), 3275-3323; doi:10.3390/ph3103275
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Cannabinoids and Reproduction: A Lasting and Intriguing History

1,†, 1,†, 1,†, 1, 1, 1,* , 2,# and 1,#
Received: 12 August 2010 / Revised: 9 September 2010 / Accepted: 21 October 2010 / Published: 25 October 2010
(This article belongs to the Special Issue Cannabinoids)
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Abstract

Starting from an historical overview of lasting Cannabis use over the centuries, we will focus on a description of the cannabinergic system, with a comprehensive analysis of chemical and pharmacological properties of endogenous and synthetic cannabimimetic analogues. The metabolic pathways and the signal transduction mechanisms, activated by cannabinoid receptors stimulation, will also be discussed. In particular, we will point out the action of cannabinoids and endocannabinoids on the different neuronal networks involved in reproductive axis, and locally, on male and female reproductive tracts, by emphasizing the pivotal role played by this system in the control of fertility.
Keywords: cannabinergic system, male reproduction, female reproduction, hypothalamus-pituitary-gonads axis. cannabinergic system, male reproduction, female reproduction, hypothalamus-pituitary-gonads axis.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cacciola, G.; Chianese, R.; Chioccarelli, T.; Ciaramella, V.; Fasano, S.; Pierantoni, R.; Meccariello, R.; Cobellis, G. Cannabinoids and Reproduction: A Lasting and Intriguing History. Pharmaceuticals 2010, 3, 3275-3323.

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