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Pharmaceuticals 2010, 3(10), 3143-3166; doi:10.3390/ph3103143

Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function

1
Department of Psychology & Sociology, Ohio Northern University, Ada, OH 43222 USA
2
Servier International, 35 rue de Verdun, 92284 Suresnes, France
3
Research & Development Service, James A. Haley VA Hospital, Tampa, FL 33612, USA
4
Department of Psychology, Cognitive and Neural Sciences Division, University of South Florida, Tampa, FL 33612, USA
5
Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA
*
Author to whom correspondence should be addressed.
Received: 19 July 2010 / Revised: 26 August 2010 / Accepted: 31 August 2010 / Published: 11 October 2010
(This article belongs to the Special Issue Antidepressants)
View Full-Text   |   Download PDF [116 KB, uploaded 11 October 2010]   |  

Abstract

Tianeptine is a well-described antidepressant which has been shown to prevent stress from producing deleterious effects on brain structure and function. Preclinical studies have shown that tianeptine blocks stress-induced alterations of neuronal morphology and synaptic plasticity. Moreover, tianeptine prevents stress from impairing learning and memory, and, importantly, demonstrates memory-enhancing properties in the absence of stress. Recent research has indicated that tianeptine works by normalizing glutamatergic neurotransmission, a mechanism of action that may underlie its effectiveness as an antidepressant. These findings emphasize the value in focusing on the mechanisms of action of tianeptine, and specifically, the glutamatergic system, in the development of novel pharmacotherapeutic strategies in the treatment of depression. View Full-Text
Keywords: antidepressant; synaptic plasticity; memory; animal model; glutamate; stress antidepressant; synaptic plasticity; memory; animal model; glutamate; stress
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zoladz, P.R.; Muñoz, C.; Diamond, D.M. Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function. Pharmaceuticals 2010, 3, 3143-3166.

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