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Pharmaceuticals 2010, 3(10), 3143-3166; doi:10.3390/ph3103143
Review

Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function

1, 2 and 3,4,5,*
Received: 19 July 2010 / Revised: 26 August 2010 / Accepted: 31 August 2010 / Published: 11 October 2010
(This article belongs to the Special Issue Antidepressants)
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Abstract

Tianeptine is a well-described antidepressant which has been shown to prevent stress from producing deleterious effects on brain structure and function. Preclinical studies have shown that tianeptine blocks stress-induced alterations of neuronal morphology and synaptic plasticity. Moreover, tianeptine prevents stress from impairing learning and memory, and, importantly, demonstrates memory-enhancing properties in the absence of stress. Recent research has indicated that tianeptine works by normalizing glutamatergic neurotransmission, a mechanism of action that may underlie its effectiveness as an antidepressant. These findings emphasize the value in focusing on the mechanisms of action of tianeptine, and specifically, the glutamatergic system, in the development of novel pharmacotherapeutic strategies in the treatment of depression.
Keywords: antidepressant; synaptic plasticity; memory; animal model; glutamate; stress antidepressant; synaptic plasticity; memory; animal model; glutamate; stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zoladz, P.R.; Muñoz, C.; Diamond, D.M. Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function. Pharmaceuticals 2010, 3, 3143-3166.

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