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Pharmaceuticals 2010, 3(12), 3522-3542; doi:10.3390/ph3123522
Review

Atypical Antipsychotics and Other Therapeutic Options for Treatment of Resistant Major Depressive Disorder

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Received: 1 November 2010; in revised form: 24 November 2010 / Accepted: 2 December 2010 / Published: 3 December 2010
(This article belongs to the Special Issue Antidepressants)
View Full-Text   |   Download PDF [161 KB, updated 8 December 2010; original version uploaded 3 December 2010]
Abstract: Antidepressant therapies, such as selective serotonin reuptake inhibitors (SSRIs), are current first-line treatments for Major Depressive Disorder. However, over 50% of treated patients show an inadequate response to initial antidepressant therapy. If the therapeutic outcomes from two antidepressant therapies are suboptimal, potentially resulting in Treatment Resistant Depression, subsequent strategies include switching to another antidepressant or augmenting treatment by combining with other agents. When combined with SSRIs, atypical antipsychotics have supplementary action on dopaminergic and noradrenergic systems. Studies on combined treatment with atypical antipsychotics have shown significantly increased remission rates, shortened response times, and favorable side effects. Augmentation of antidepressants with atypical antipsychotics is now an acceptable treatment strategy which leads to increased remission rates and better outcomes for patients.
Keywords: treatment resistant disorder; major depressive disorder; augmentation; atypical antipsychotic; typical antipsychotic; antidepressant; selective serotonin reuptake inhibitor; electroconvulsive therapy treatment resistant disorder; major depressive disorder; augmentation; atypical antipsychotic; typical antipsychotic; antidepressant; selective serotonin reuptake inhibitor; electroconvulsive therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Seo, R.J.; MacPherson, H.; Young, A.H. Atypical Antipsychotics and Other Therapeutic Options for Treatment of Resistant Major Depressive Disorder. Pharmaceuticals 2010, 3, 3522-3542.

AMA Style

Seo RJ, MacPherson H, Young AH. Atypical Antipsychotics and Other Therapeutic Options for Treatment of Resistant Major Depressive Disorder. Pharmaceuticals. 2010; 3(12):3522-3542.

Chicago/Turabian Style

Seo, Rubo J.; MacPherson, Holly; Young, Allan H. 2010. "Atypical Antipsychotics and Other Therapeutic Options for Treatment of Resistant Major Depressive Disorder." Pharmaceuticals 3, no. 12: 3522-3542.



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