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• Reese, A
• Hardin, J
• Cheng, I
• Casey, G
• Witte, J
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• Reese, A
• Hardin, J
• Cheng, I
• Casey, G
• Witte, J
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• Reese, A
• Hardin, J
• Cheng, I
• Casey, G
• Witte, J

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Pharmaceuticals 2010, 3(10), 3127-3142; doi:10.3390/ph3103127

Article

Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer

Adam C. Reese ¹ , Jill Hardin ² , Iona Cheng ³ , Graham Casey ⁴  and John S. Witte ^1,2,*

¹ Department of Urology, University of California at San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA ² Epidemiology and Biostatistics and Institute for Human Genetics, University of California at San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA ³ Epidemiology Program, Cancer Research Center of Hawai`i, University of Hawai`i, Honolulu, HI 96813, USA ⁴ Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA

* Author to whom correspondence should be addressed.

Received: 9 August 2010; in revised form: 27 September 2010 / Accepted: 28 September 2010 / Published: 8 October 2010

(This article belongs to the Special Issue Non-Steroidal Anti-Inflammatory Drugs)

Download PDF Full-Text [123 KB, uploaded 8 October 2010 15:26 CEST]

Abstract: Increasing evidence suggests that prostatic inflammation plays a key role in the development of prostate cancer. It remains controversial whether non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of prostate cancer. Here, we investigate how a previously reported inverse association between NSAID use and the risk of aggressive prostate cancer is modulated by variants in several inflammatory genes. We found that NSAIDs may have differential effects on prostate cancer development, depending on one’s genetic makeup. Further study of these inflammatory pathways may clarify the mechanisms through which NSAIDs impact prostate cancer risk.

Keywords: prostatic neoplasms; non-steroidal anti-inflammatory agents; aspirin; genetic variation; single nucleotide polymorphism

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