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Pharmaceuticals 2010, 3(10), 3021-3039; doi:10.3390/ph3103021

Endogenous Matrix-Derived Inhibitors of Angiogenesis

1,* , 2
1 Department of Surgery, Umea University Hospital, Umea University, SE-90185 Umea, Sweden 2 Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland 3 Department of Oncology, Institute of Medicine, Haukeland University Hospital, University of Bergen, Bergen, Norway
* Author to whom correspondence should be addressed.
Received: 10 August 2010 / Revised: 19 September 2010 / Accepted: 25 September 2010 / Published: 28 September 2010
(This article belongs to the Special Issue Angiogenesis Inhibitors)
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Endogenous inhibitors of angiogenesis are proteins or fragments of proteins that are formed in the body, which can inhibit the angiogenic process. These molecules can be found both in the circulation and sequestered in the extracellular matrix (ECM) surrounding cells. Many matrix-derived inhibitors of angiogenesis, such as endostatin, tumstatin, canstatin and arresten, are bioactive fragments of larger ECM molecules. These substances become released upon proteolysis of the ECM and the vascular basement membrane (VBM) by enzymes of the tumor microenvironment. Although the role of matrix-derived angiogenesis inhibitors is well studied in animal models of cancer, their role in human cancers is less established. In this review we discuss the current knowledge about these molecules and their potential use as cancer therapeutics and biomarkers.
Keywords: angiogenesis; extracellular matrix; collagen; cancer; therapy; biomarker angiogenesis; extracellular matrix; collagen; cancer; therapy; biomarker
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sund, M.; Nyberg, P.; Eikesdal, H.P. Endogenous Matrix-Derived Inhibitors of Angiogenesis. Pharmaceuticals 2010, 3, 3021-3039.

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