Pharmaceuticals 2010, 3(9), 3005-3020; doi:10.3390/ph3093005
Review

Oral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of ActionOral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of Action

Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
* Author to whom correspondence should be addressed.
Received: 29 July 2010; in revised form: 3 September 2010 / Accepted: 6 September 2010 / Published: 15 September 2010
(This article belongs to the Special Issue Antidiabetic Drugs)
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Abstract: Type 2 diabetes is a syndrome characterized by relative insulin deficiency, insulin resistance and increased hepatic glucose output. Medications used to treat the disease are designed to correct one or more of these metabolic abnormalities. Current recommendations of the American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) include diet and exercise as first-line therapy plus hypoglycemic drugs. Actually there are seven distinct classes of anti-hyperglicemic agents, each of them displaying unique pharmacologic properties. The aim of this review is to describe the pathophysiological basis of their mechanism of action, a necessary step to individualize treatment of diabetic people, taking into proper consideration potential benefits and secondary effects of drugs.
Keywords: hypoglycemic drugs; sulfonylureas; thiazolidinediones; incretin mimeticshypoglycemic drugs; sulfonylureas; thiazolidinediones; incretin mimetics

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MDPI and ACS Style

Lorenzati, B.; Zucco, C.; Miglietta, S.; Lamberti, F.; Bruno, G. Oral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of ActionOral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of Action. Pharmaceuticals 2010, 3, 3005-3020.

AMA Style

Lorenzati B, Zucco C, Miglietta S, Lamberti F, Bruno G. Oral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of ActionOral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of Action. Pharmaceuticals. 2010; 3(9):3005-3020.

Chicago/Turabian Style

Lorenzati, Bartolomeo; Zucco, Chiara; Miglietta, Sara; Lamberti, Federico; Bruno, Graziella. 2010. "Oral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of ActionOral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of Action." Pharmaceuticals 3, no. 9: 3005-3020.

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