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Pharmaceuticals 2010, 3(1), 237-250; doi:10.3390/ph3010237
Review

Quercetin: A Treatment for Hypertension?—A Review of Efficacy and Mechanisms

1
, 1
 and 2,*
Received: 8 December 2009; in revised form: 12 January 2010 / Accepted: 14 January 2010 / Published: 19 January 2010
(This article belongs to the Special Issue Antihypertensive Drugs)
View Full-Text   |   Download PDF [108 KB, uploaded 20 January 2010]
Abstract: Quercetin is a polyphenolic flavonoid. Common sources in the diet are apples, onions, berries, and red wine. Epidemiological studies have found an inverse relationship between dietary quercetin intake and cardiovascular disease. This has led to in vitro, in vivo, and clinical research to determine the mechanism by which quercetin exerts cardioprotective effects. Recent studies have found a reduction in blood pressure when hypertensive (>140 mm Hg systolic and >90 mm Hg diastolic) animals and humans are supplemented with quercetin. Proposed mechanisms for the antihypertensive effect of quercetin include decreased oxidative stress, inhibition of angiotensin converting enzyme activity, improved endothelial function, direct action on the vascular smooth muscle, and/or modulation in cell signaling and gene expression. Although in vitro and in vivo evidence exists to support and refute each possibility, it is likely that quercetin influences multiple targets via a combination of known and as yet undiscovered mechanisms. The purpose of this review is to examine the mechanisms whereby quercetin might reduce blood pressure in hypertensive individuals.
Keywords: quercetin; hypertension; angiotensin converting enzyme; endothelial function; antioxidants quercetin; hypertension; angiotensin converting enzyme; endothelial function; antioxidants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Larson, A.J.; Symons, J.D.; Jalili, T. Quercetin: A Treatment for Hypertension?—A Review of Efficacy and Mechanisms. Pharmaceuticals 2010, 3, 237-250.

AMA Style

Larson AJ, Symons JD, Jalili T. Quercetin: A Treatment for Hypertension?—A Review of Efficacy and Mechanisms. Pharmaceuticals. 2010; 3(1):237-250.

Chicago/Turabian Style

Larson, Abigail J.; Symons, J. David; Jalili, Thunder. 2010. "Quercetin: A Treatment for Hypertension?—A Review of Efficacy and Mechanisms." Pharmaceuticals 3, no. 1: 237-250.


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