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Pharmaceuticals 2010, 3(1), 225-236; doi:10.3390/ph3010225
Article

A New Baroreceptor Sensitivity-Restoring Ca-Channel Blocker Diminishes Age-Related Morning Blood Pressure Increase in Hypertensive Patients: Open-Label Monitoring of Azelnidipine Treatment for Hypertension in the Early Morning (At-HOME) Study

1,* , 2, 2, 2, 2 and 1
Received: 1 December 2009; in revised form: 28 December 2009 / Accepted: 5 January 2010 / Published: 19 January 2010
(This article belongs to the Special Issue Antihypertensive Drugs)
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Abstract: Background: Morning blood pressure (BP) surge, which exhibits an age-related increase, is a risk factor for stroke in elderly hypertensive patients, independently of the 24-h BP level. We studied the effect of the new baroreceptor sensitivity (BRS)-restoring Ca-channel blocker (CCB) azelnidipine (AZ) on this age-related morning BP increase. Methods: We conducted a 16-week prospective study to clarify the effect of morning dosing of AZ on home BPs measured in the morning and in the evening in 2,546 hypertensive patients (mean age, 65.1 years; female, 53.6%). Results: At baseline, ME-Dif (morning systolic BP [SBP]–evening SBP) increased with age, independently of ME-Ave (average of the morning and evening SBPs). This age-related increase of ME-Dif was exaggerated by regular alcohol drinking and beta-blocker use. After AZ treatment (14.3 ± 3.6 mg/day), ME-AV and ME-Dif were significantly reduced independently of each other, with reductions of –18.1 ± 15.6 and –2.5 ± 13.2 mmHg, respectively (both p < 0.001). AZ treatment decreased age-related increase in ME-Dif particularly in patients who were regular consumers of alcohol and in beta-blocker users. Conclusions: The new BRS-restoring CCB AZ significantly reduced age-related increase in morning BP and had some potential benefit on cardiovascular protection in hypertension, particularly in elderly patients and/or consumers of alcohol.
Keywords: ca-channel blocker (CCB); azelnidipine (AZ); morning hypertension; morning-evening blood pressure difference (ME-Dif) ca-channel blocker (CCB); azelnidipine (AZ); morning hypertension; morning-evening blood pressure difference (ME-Dif)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kario, K.; Shirayama, M.; Hiramatsu, K.; Shiosakai, K.; Sugiyama, M.; Shimada, K. A New Baroreceptor Sensitivity-Restoring Ca-Channel Blocker Diminishes Age-Related Morning Blood Pressure Increase in Hypertensive Patients: Open-Label Monitoring of Azelnidipine Treatment for Hypertension in the Early Morning (At-HOME) Study. Pharmaceuticals 2010, 3, 225-236.

AMA Style

Kario K, Shirayama M, Hiramatsu K, Shiosakai K, Sugiyama M, Shimada K. A New Baroreceptor Sensitivity-Restoring Ca-Channel Blocker Diminishes Age-Related Morning Blood Pressure Increase in Hypertensive Patients: Open-Label Monitoring of Azelnidipine Treatment for Hypertension in the Early Morning (At-HOME) Study. Pharmaceuticals. 2010; 3(1):225-236.

Chicago/Turabian Style

Kario, Kazuomi; Shirayama, Masayuki; Hiramatsu, Katsutoshi; Shiosakai, Kazuhito; Sugiyama, Mitsunori; Shimada, Kazuyuki. 2010. "A New Baroreceptor Sensitivity-Restoring Ca-Channel Blocker Diminishes Age-Related Morning Blood Pressure Increase in Hypertensive Patients: Open-Label Monitoring of Azelnidipine Treatment for Hypertension in the Early Morning (At-HOME) Study." Pharmaceuticals 3, no. 1: 225-236.



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