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Sensors 2009, 9(9), 7003-7020; doi:10.3390/s90907003

Primary Cilia: Highly Sophisticated Biological Sensors

Pharmacology Department; MS 607 / University of Toledo, 2801 W. Bancroft Street, Toledo, OH 43606, USA
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Received: 2 July 2009 / Revised: 31 July 2009 / Accepted: 1 September 2009 / Published: 3 September 2009
(This article belongs to the Section Biosensors)
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Abstract

Primary cilia, thin hair-like structures protruding from the apical surface of most mammalian cells, have gained the attention of many researchers over the past decade. Primary cilia are microtubule-filled sensory organelles that are enclosed within the ciliary membrane. They originate at the cell surface from the mother centriole that becomes the mature basal body. In this review, we will discuss recent literatures on the roles of cilia as sophisticated sensory organelles. With particular emphasis on vascular endothelia and renal epithelia, the mechanosensory role of cilia in sensing fluid shear stress will be discussed. Also highlighted is the ciliary involvement in cell cycle regulation, development, cell signaling and cancer. Finally, primary cilia-related disorders will be briefly described. View Full-Text
Keywords: primary cilia; mechanosensory transduction; calcium; fluid shear stress primary cilia; mechanosensory transduction; calcium; fluid shear stress
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Abou Alaiwi, W.A.; Lo, S.T.; Nauli, S.M. Primary Cilia: Highly Sophisticated Biological Sensors. Sensors 2009, 9, 7003-7020.

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