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Sensors 2009, 9(4), 2437-2445; doi:10.3390/s90402437

Article

Electrochemical Direct Determination of Catecholamines for the Early Detection of Neurodegenerative Diseases

Antonella Curulli

Institute of Nanostructured Materials (ISMN) CNR Division 2, via del Castro Laurenziano 7, 00161 Rome, Italy

Received: 26 February 2009; in revised form: 1 April 2009 / Accepted: 7 April 2009 / Published: 7 April 2009

(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Italy)

Download PDF Full-Text [129 KB, uploaded 7 April 2009 13:30 CEST]

Abstract: Smart (Nano) materials with biosensing functions posses enormous potential in development of new generation of stable biosensors, chemical sensors, and actuators. Recently, there is a considerable interest in using TiO₂ nanostructured materials as a film-forming material since they have high surface area, optical transparency, high bio-compatibility, and relatively good conductivity. In this work, TiO₂ nanostructured films were used as nanoporous electrodes to study the electron transfer mechanisms of dopamine. epinephrine and norepinephrine, in order to develop a new generation of chemical sensors. The interesting results obtained are described herein and the analytical characterization of these neurotransmitter sensors is reported.

Keywords: TiO2 nanostructured films; chemical sensors; monoamine-neurotransmitters; electrochemical transducers

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