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Sensors 2009, 9(3), 1590-1598; doi:10.3390/s90301590

Ultra-Fast Low Concentration Detection of Candida Pathogens Utilizing High Resolution Micropore Chips

1
Department of Mechanical Engineering & Mechanics, Drexel University, Philadelphia, PA 19104, U.S.A
2
Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, U.S.A.
*
Author to whom correspondence should be addressed.
Received: 9 January 2009 / Revised: 26 February 2009 / Accepted: 2 March 2009 / Published: 9 March 2009
(This article belongs to the Section Biosensors)
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Abstract

Although Candida species are the fourth most common cause of nosocomial blood stream infections in the United States, early diagnostic tools for invasive candidemia are lacking. Due to an increasing rate of candidemia, a new screening system is needed to detect the Candida species in a timely manner. Here we describe a novel method of detection using a solid-state micro-scale pore similar to the operational principles of a Coulter counter. With a steady electrolyte current flowing through the pore, measurements are taken of changes in the current corresponding to the shape of individual yeasts as they translocate or travel through the pore. The direct ultra-fast low concentration electrical addressing of C. albicans has established criteria for distinguishing individual yeast based on their structural properties, which may reduce the currently used methods’ complexity for both identification and quantification capabilities in mixed blood samples View Full-Text
Keywords: Candida; low concentration detection; ionic current blockage; micropore; pathogens Candida; low concentration detection; ionic current blockage; micropore; pathogens
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Mulero, R.; Lee, D.H.; Kutzler, M.A.; Jacobson, J.M.; Kim, M.J. Ultra-Fast Low Concentration Detection of Candida Pathogens Utilizing High Resolution Micropore Chips. Sensors 2009, 9, 1590-1598.

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