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Sensors 2009, 9(12), 9965-9976; doi:10.3390/s91209965

Polyester Sulphonic Acid Interstitial Nanocomposite Platform for Peroxide Biosensor

SensorLab, Department of Chemistry, University of Western Cape, Bellville, 7535, Cape Town, South Africa
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Received: 16 November 2009 / Revised: 25 November 2009 / Accepted: 7 December 2009 / Published: 8 December 2009
(This article belongs to the Section Biosensors)
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Abstract

A novel enzyme immobilization platform was prepared on a platinum disk working electrode by polymerizing aniline inside the interstitial pores of polyester sulphonic acid sodium salt (PESA). Scanning electron microscopy study showed the formation of homogeneous sulphonated polyaniline (PANI) nanotubes (~90 nm) and thermogravimetric analysis (TGA) confirmed that the nanotubes were stable up to 230 °C. The PANI:PESA nanocomposite showed a quasi-reversible redox behaviour in phosphate buffer saline. Horseradish peroxidase (HRP) was immobilized on to this modified electrode for hydrogen peroxide detection. The biosensor gave a sensitivity of 1.33 μA (μM)-1 and a detection limit of 0.185 μM for H2O2. Stability experiments showed that the biosensor retained more than 64% of its initial sensitivity over four days of storage at 4 °C. View Full-Text
Keywords: peroxide biosensors; immobilization of enzyme; HRP; electrochemical polymerisation; polyaniline nanotubes; polyester sulphonic acid peroxide biosensors; immobilization of enzyme; HRP; electrochemical polymerisation; polyaniline nanotubes; polyester sulphonic acid
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Al-Ahmed, A.; Ndangili, P.M.; Jahed, N.; Baker, P.G.L.; Iwuoha, E.I. Polyester Sulphonic Acid Interstitial Nanocomposite Platform for Peroxide Biosensor. Sensors 2009, 9, 9965-9976.

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