Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Sensors 2009, 9(12), 10356-10388; doi:10.3390/s91210356
Review

Aptamer-Functionalized Nano-Biosensors

1,*  and 2,*
Received: 22 October 2009; in revised form: 3 December 2009 / Accepted: 3 December 2009 / Published: 21 December 2009
(This article belongs to the Special Issue DNA Sensors and Biosensors)
View Full-Text   |   Download PDF [1369 KB, uploaded 21 June 2014]
Abstract: Nanomaterials have become one of the most interesting sensing materials because of their unique size- and shape-dependent optical properties, high surface energy and surface-to-volume ratio, and tunable surface properties. Aptamers are oligonucleotides that can bind their target ligands with high affinity. The use of nanomaterials that are bioconjugated with aptamers for selective and sensitive detection of analytes such as small molecules, metal ions, proteins, and cells has been demonstrated. This review focuses on recent progress in the development of biosensors by integrating functional aptamers with different types of nanomaterials, including quantum dots, magnetic nanoparticles (NPs), metallic NPs, and carbon nanotubes. Colorimetry, fluorescence, electrochemistry, surface plasmon resonance, surface-enhanced Raman scattering, and magnetic resonance imaging are common detection modes for a broad range of analytes with high sensitivity and selectivity when using aptamer bioconjugated nanomaterials (Apt-NMs). We highlight the important roles that the size and concentration of nanomaterials, the secondary structure and density of aptamers, and the multivalent interactions play in determining the specificity and sensitivity of the nanosensors towards analytes. Advantages and disadvantages of the Apt-NMs for bioapplications are focused.
Keywords: nanomaterials; aptamers; biosensors; metal ions; proteins; cells nanomaterials; aptamers; biosensors; metal ions; proteins; cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Chiu, T.-C.; Huang, C.-C. Aptamer-Functionalized Nano-Biosensors. Sensors 2009, 9, 10356-10388.

AMA Style

Chiu T-C, Huang C-C. Aptamer-Functionalized Nano-Biosensors. Sensors. 2009; 9(12):10356-10388.

Chicago/Turabian Style

Chiu, Tai-Chia; Huang, Chih-Ching. 2009. "Aptamer-Functionalized Nano-Biosensors." Sensors 9, no. 12: 10356-10388.


Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert