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Development of a Molecularly Imprinted Biomimetic Electrode
Department of Biosystems and Agricultural Engineering, Michigan State University, 204 Farrall Hall, East Lansing, MI 48824, USA
* Author to whom correspondence should be addressed.
Received: 30 April 2007; Accepted: 23 August 2007 / Published: 27 August 2007
Abstract: The technique of molecular imprinting produces artificial receptor sites in apolymer that can be used in a biomimetic sensor. This research extends previous studies ofa molecularly imprinted polymer (MIP) biomimetic sensor for the small drug theophylline.The presence of theophylline in the biomimetic sensor was monitored by analyzing thepeak currents from cyclic voltammetry experiments. The functional working range of theMIP modified electrode was 2 - 4 mM theophylline. The concentration of theophyllinethat resulted in the best signal was 3 mM. The MIP sensor showed no response to thestructurally related molecule caffeine, and therefore was selective to the target analytetheophylline. This research will provide the foundation for future studies that will result indurable biomimetic sensors that can offer a viable alternative to current sensors.
Keywords: Molecularly imprinted polymer; Molecular imprinting; Biomimetic sensor; Indium tin oxide; Cyclic voltammetry; Theophylline
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MDPI and ACS Style
Kindschy, L.M.; Alocilja, E.C. Development of a Molecularly Imprinted Biomimetic Electrode. Sensors 2007, 7, 1630-1642.
Kindschy LM, Alocilja EC. Development of a Molecularly Imprinted Biomimetic Electrode. Sensors. 2007; 7(8):1630-1642.
Kindschy, Lisa M.; Alocilja, Evangelyn C. 2007. "Development of a Molecularly Imprinted Biomimetic Electrode." Sensors 7, no. 8: 1630-1642.