Abstract: Recently, the polymeric micro-fluidic biochip, often called LOC (lab-on-a-chip), has been focused as a cheap, rapid and simplified method to replace the existing biochemical laboratory works. It becomes possible to form miniaturized lab functionalities on a chip with the development of MEMS technologies. The micro-fluidic chips contain many micro-channels for the flow of sample and reagents, mixing, and detection tasks. Typical substrate materials for the chip are glass and polymers. Typical techniques for micro-fluidic chip fabrication are utilizing various micro pattern forming methods, such as wet-etching, micro-contact printing, and hot-embossing, micro injection molding, LIGA, and micro powder blasting processes, etc. In this study, to establish the basis of the micro pattern fabrication and mass production of polymeric micro-fluidic chips using injection molding process, micro machining method was applied to form micro-channels on the LOC molds. In the research, a series of machining experiments using micro end-mills were performed to determine optimum machining conditions to improve surface roughness and shape accuracy of designed simplified micro-channels. Obtained conditions were used to machine required mold inserts for micro-channels using micro end-mills. Test injection processes using machined molds and COC polymer were performed, and then the results were investigated.
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Jung, W.-C.; Heo, Y.-M.; Yoon, G.-S.; Shin, K.-H.; Chang, S.-H.; Kim, G.-H.; Cho, M.-W. Micro Machining of Injection Mold Inserts for Fluidic Channel of Polymeric Biochips. Sensors 2007, 7, 1643-1654.
Jung W-C, Heo Y-M, Yoon G-S, Shin K-H, Chang S-H, Kim G-H, Cho M-W. Micro Machining of Injection Mold Inserts for Fluidic Channel of Polymeric Biochips. Sensors. 2007; 7(8):1643-1654.
Jung, Woo-Chul; Heo, Young-Moo; Yoon, Gil-Sang; Shin, Kwang-Ho; Chang, Sung-Ho; Kim, Gun-Hee; Cho, Myeong-Woo. 2007. "Micro Machining of Injection Mold Inserts for Fluidic Channel of Polymeric Biochips." Sensors 7, no. 8: 1643-1654.