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Sensors 2007, 7(9), 1667-1682; doi:10.3390/s7091667
Article
Mechanosensor Channels in Mammalian Somatosensory Neurons
Matthieu Raoux
, Lise Rodat-Despoix, Nathalie Azorin, Aurélie Giamarchi, Jizhe Hao, François Maingret, Marcel Crest, Bertrand Coste and Patrick Delmas*
, Lise Rodat-Despoix, Nathalie Azorin, Aurélie Giamarchi, Jizhe Hao, François Maingret, Marcel Crest, Bertrand Coste and Patrick Delmas*
Laboratoire de Neurophysiologie Cellulaire, Centre National de la Recherche Scientifique UMR 6150, Université de la Méditerranée, Marseille, France
* Author to whom correspondence should be addressed.
Received: 10 August 2007 / Accepted: 31 August 2007 / Published: 3 September 2007
(This article belongs to the Special Issue Physiological Sensing)
Download PDF Full-Text [285 KB, uploaded 20 June 2008 16:52 CEST]
Abstract: Mechanoreceptive sensory neurons innervating the skin, skeletal muscles andviscera signal both innocuous and noxious information necessary for proprioception, touchand pain. These neurons are responsible for the transduction of mechanical stimuli intoaction potentials that propagate to the central nervous system. The ability of these cells todetect mechanical stimuli impinging on them relies on the presence of mechanosensitivechannels that transduce the external mechanical forces into electrical and chemical signals.Although a great deal of information regarding the molecular and biophysical properties ofmechanosensitive channels in prokaryotes has been accumulated over the past two decades,less is known about the mechanosensitive channels necessary for proprioception and thesenses of touch and pain. This review summarizes the most pertinent data onmechanosensitive channels of mammalian somatosensory neurons, focusing on theirproperties, pharmacology and putative identity.
Keywords: Pain; Touch; Skin sensation; Mechanosensory transduction; Stretch; Osmotic shock; Mechanosensitive channels; TRP channels; ASIC; amiloride; DRG.
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MDPI and ACS Style
Raoux, M.; Rodat-Despoix, L.; Azorin, N.; Giamarchi, A.; Hao, J.; Maingret, F.; Crest, M.; Coste, B.; Delmas, P. Mechanosensor Channels in Mammalian Somatosensory Neurons. Sensors 2007, 7, 1667-1682.
AMA StyleRaoux M, Rodat-Despoix L, Azorin N, Giamarchi A, Hao J, Maingret F, Crest M, Coste B, Delmas P. Mechanosensor Channels in Mammalian Somatosensory Neurons. Sensors. 2007; 7(9):1667-1682.
Chicago/Turabian StyleRaoux, Matthieu; Rodat-Despoix, Lise; Azorin, Nathalie; Giamarchi, Aurélie; Hao, Jizhe; Maingret, François; Crest, Marcel; Coste, Bertrand; Delmas, Patrick. 2007. "Mechanosensor Channels in Mammalian Somatosensory Neurons." Sensors 7, no. 9: 1667-1682.