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Sensors 2007, 7(11), 2671-2680; doi:10.3390/s7112671
Article

Electrochemical Interrogation of Interactions between Surface-Confined DNA and Methylene Blue

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Received: 31 October 2007; Accepted: 9 November 2007 / Published: 12 November 2007
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Abstract: In this work, we reported a systematic investigation on the interactions betweenmethylene blue (MB) and surface-confined DNA by using electrochemical methods. Wedemonstrated that the redox potential of MB and binding and dissociation kinetics of MB toDNA differed significantly for single-stranded DNA (ss-DNA) and double-stranded DNA(ds-DNA) immobilized on gold electrodes. This was possibly due to the different bindingmechanism between MB and ss- or ds-DNA. This work might provide useful informationfor developing MB-based sequence-specific electrochemical DNA sensors.
Keywords: Electrochemical DNA sensors; methylene blue; electrochemical indicators. Electrochemical DNA sensors; methylene blue; electrochemical indicators.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pan, D.; Zuo, X.; Wan, Y.; Wang, L.; Zhang, J.; Song, S.; Fan, C. Electrochemical Interrogation of Interactions between Surface-Confined DNA and Methylene Blue. Sensors 2007, 7, 2671-2680.

AMA Style

Pan D, Zuo X, Wan Y, Wang L, Zhang J, Song S, Fan C. Electrochemical Interrogation of Interactions between Surface-Confined DNA and Methylene Blue. Sensors. 2007; 7(11):2671-2680.

Chicago/Turabian Style

Pan, Dun; Zuo, Xiaolei; Wan, Ying; Wang, Lihua; Zhang, Jiong; Song, Shiping; Fan, Chunhai. 2007. "Electrochemical Interrogation of Interactions between Surface-Confined DNA and Methylene Blue." Sensors 7, no. 11: 2671-2680.



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