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Sensors 2006, 6(8), 925-953; doi:10.3390/s6080925

Biosensing with Luminescent Semiconductor Quantum Dots

1
Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375-5320, USA
2
Division of Optical Sciences, Code 5611, U.S. Naval Research Laboratory, Washington, DC 20375-5320, USA.
3
George Mason University, 10910 University Blvd, MS 4E3, Manassas, VA 20110 USA.
4
Chemical & Biomolecular Eng. Dept. Johns Hopkins University, Baltimore, MD 21218 USA
*
Authors to whom correspondence should be addressed.
Received: 12 April 2006 / Accepted: 9 June 2005 / Published: 24 August 2006
(This article belongs to the Special Issue Supramolecular Sensors)
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Abstract

Luminescent semiconductor nanocrystals or quantum dots (QDs) are a recentlydeveloped class of nanomaterial whose unique photophysical properties are helping tocreate a new generation of robust fluorescent biosensors. QD properties of interest forbiosensing include high quantum yields, broad absorption spectra coupled to narrow sizetunablephotoluminescent emissions and exceptional resistance to both photobleaching andchemical degradation. In this review, we examine the progress in adapting QDs for severalpredominantly in vitro biosensing applications including use in immunoassays, asgeneralized probes, in nucleic acid detection and fluorescence resonance energy transfer(FRET) - based sensing. We also describe several important considerations when workingwith QDs mainly centered on the choice of material(s) and appropriate strategies forattaching biomolecules to the QDs.
Keywords: Biosensor; fluorescence; antibody; DNA; detection; FRET; quantum dot; probe; immunoassay; nanocrystal. Biosensor; fluorescence; antibody; DNA; detection; FRET; quantum dot; probe; immunoassay; nanocrystal.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Sapsford, K.E.; Pons, T.; Medintz, I.L.; Mattoussi, H. Biosensing with Luminescent Semiconductor Quantum Dots. Sensors 2006, 6, 925-953.

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