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Long-Term Monitoring of Brain Dopamine Metabolism In Vivo with Carbon Paste Electrodes
Sensors 2005, 5(11), 473-487; doi:10.3390/s5110473
Article

Brain Tissue Oxygen: In Vivo Monitoring with Carbon Paste Electrodes

 and *
Received: 28 April 2005 / Accepted: 1 July 2005 / Published: 16 November 2005
(This article belongs to the Special Issue Carbon Paste Electrodes)
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Abstract

In this communication we review selected experiments involving the use ofcarbon paste electrodes (CPEs) to monitor and measure brain tissue O2 levels in awakefreely-moving animals. Simultaneous measurements of rCBF were performed using the H2clearance technique. Voltammetric techniques used include both differential pulse (O2) andconstant potential amperometry (rCBF). Mild hypoxia and hyperoxia produced rapidchanges (decrease and increase respectively) in the in vivo O2 signal. Neuronal activation(tail pinch and stimulated grooming) produced similar increases in both O2 and rCBFindicating that CPE O2 currents provide an index of increases in rCBF when such increasesexceed O2 utilization. Saline injection produced a transient increase in the O2 signal whilechloral hydrate produced slower more long-lasting changes that accompanied the behavioralchanges associated with anaesthesia. Acetazolamide increased O2 levels through an increasein rCBF.
Keywords: In-vivo voltammetry; cerebral blood flow; hypoxia and hyperoxia; neuronal activation; chloral hydrate anaesthesia; acetazolamide In-vivo voltammetry; cerebral blood flow; hypoxia and hyperoxia; neuronal activation; chloral hydrate anaesthesia; acetazolamide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bolger, F.B.; Lowry, J.P. Brain Tissue Oxygen: In Vivo Monitoring with Carbon Paste Electrodes. Sensors 2005, 5, 473-487.

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