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Sensors 2017, 17(2), 221; doi:10.3390/s17020221

Microshell Arrays Enhanced Sensitivity in Detection of Specific Antibody for Reduced Graphene Oxide Optical Sensor

1
The Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, Teda Applied Physics School and School of Physics, Nankai University, Tianjin 300071, China
2
The 2011 Project Collaborative Innovation Center for Biological Therapy, Nankai University, Tianjin 300071, China
*
Author to whom correspondence should be addressed.
Academic Editor: Robert Rubin
Received: 19 November 2016 / Revised: 14 January 2017 / Accepted: 18 January 2017 / Published: 24 January 2017
(This article belongs to the Special Issue Biosensors for Antibody Detection)
View Full-Text   |   Download PDF [4080 KB, uploaded 25 January 2017]   |  

Abstract

Protein-protein interactions play an important role in the investigation of biomolecules. In this paper, we reported on the use of a reduced graphene oxide microshell (RGOM)-based optical biosensor for the determination of goat anti-rabbit IgG. The biosensor was prepared through a self-assembly of monolayers of monodisperse polystyrene microspheres, combined with a high-temperature reduction, in order to decorate the RGOM with rabbit IgG. The periodic microshells allowed a simpler functionalization and modification of RGOM with bioreceptor units, than reduced graphene oxide (RGO). With additional antibody-antigen binding, the RGOM-based biosensor achieved better real-time and label-free detection. The RGOM-based biosensor presented a more satisfactory response to goat anti-rabbit IgG than the RGO-based biosensor. This method is promising for immobilizing biomolecules on graphene surfaces and for the fabrication of biosensors with enhanced sensitivity. View Full-Text
Keywords: reduced graphene oxide; microshells; optical sensor; goat anti-rabbit IgG; real-time; label-free reduced graphene oxide; microshells; optical sensor; goat anti-rabbit IgG; real-time; label-free
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MDPI and ACS Style

Jiang, W.-S.; Xin, W.; Chen, S.-N.; Li, C.-B.; Gao, X.-G.; Pan, L.-T.; Liu, Z.-B.; Tian, J.-G. Microshell Arrays Enhanced Sensitivity in Detection of Specific Antibody for Reduced Graphene Oxide Optical Sensor. Sensors 2017, 17, 221.

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