Dear Colleagues,

An immunosensor in which antibody is the analyte of interest requires a target antigen as the antibody-capturing agent. Blood-borne antibodies can provide a highly-sensitive and specific history of an individual’s exposure to a foreign antigen, or to the presence of an inappropriate immune response to potentially antigenic materials, such as self-antigens, non-pathogenic environmental antigens, or medications. However, in contrast to immunosensors utilizing antibodies to capture molecular analytes, antibody immunosensors pose special problems due to the heterogeneity, complexity, and concentration of immunoglobulins in natural biological fluids. Consequently, the value of specific antibody measurement is principally determined by its protective, diagnostic, or pathogenic significance as assessed by clinical correlative studies and/or by comparison to standard or reference conventional antibody assays.  This can be a challenging hurdle in the development of immunosensors for antibody. Nevertheless, there is growing interest and need for rapid and reliable antibody biosensors for monitoring infectious, autoimmune, inflammatory, immune deficiency and allergic diseases as well as for spontaneous responses to tumor antigens in cancer diagnosis, to alloantigens in organ transplantation and to therapeutic macromolecules. This Special Issue of Sensors invites contributions in these and related areas focusing on development of biosensors for specific antibodies.

Prof. Dr. Robert Rubin
Guest Editor

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• Quantitative biosensors for specific antibody
• Qualitative biosensors such as line or spot biosensors
• Point-of-care applications or potential
• Isotype-restricted sensors for specific antibody
• Total specific antibody sensors
• Microfluidics and miniaturization improvements in antibody sensors
• Label-free, mediator-less antibody sensors
• Electrochemical biosensors (amperometric, coulometric, impedimetric, potentiometric)