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Sensors 2017, 17(10), 2259; https://doi.org/10.3390/s17102259

A Novel Fiber Optic Surface Plasmon Resonance Biosensors with Special Boronic Acid Derivative to Detect Glycoprotein

School of Physics and Optoelectronic Technology, Dalian University of Technology, 2 Linggong Road, Ganjingzi District, Dalian 116024, China
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Received: 31 August 2017 / Revised: 27 September 2017 / Accepted: 28 September 2017 / Published: 1 October 2017
(This article belongs to the Special Issue Surface Plasmon Resonance Sensing)
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Abstract

We proposed and demonstrated a novel tilted fiber Bragg grating (TFBG)-based surface plasmon resonance (SPR) label-free biosensor via a special boronic acid derivative to detect glycoprotein with high sensitivity and selectivity. TFBG, as an effective sensing element for optical sensing in near-infrared wavelengths, possess the unique capability of easily exciting the SPR effect on fiber surface which coated with a nano-scale metal layer. SPR properties can be accurately detected by measuring the variation of transmitted spectra at optical communication wavelengths. In our experiment, a 10° TFBG coated with a 50 nm gold film was manufactured to stimulate SPR on a sensor surface. To detect glycoprotein selectively, the sensor was immobilized using designed phenylboronic acid as the recognition molecule, which can covalently bond with 1,2- or 1,3-diols to form five- or six-membered cyclic complexes for attaching diol-containing biomolecules and proteins. The phenylboronic acid was synthetized with long alkyl groups offering more flexible space, which was able to improve the capability of binding glycoprotein. The proposed TFBG-SPR sensors exhibit good selectivity and repeatability with a protein concentration sensitivity up to 2.867 dB/ (mg/mL) and a limit of detection (LOD) of 15.56 nM. View Full-Text
Keywords: tilted fiber Bragg grating; surface plasmon resonance; boronic acid; glycoprotein tilted fiber Bragg grating; surface plasmon resonance; boronic acid; glycoprotein
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Zhang, Y.; Wang, F.; Qian, S.; Liu, Z.; Wang, Q.; Gu, Y.; Wu, Z.; Jing, Z.; Sun, C.; Peng, W. A Novel Fiber Optic Surface Plasmon Resonance Biosensors with Special Boronic Acid Derivative to Detect Glycoprotein. Sensors 2017, 17, 2259.

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