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Sensors 2016, 16(11), 1959; doi:10.3390/s16111959

Evaluation of Hyaluronic Acid Dilutions at Different Concentrations Using a Quartz Crystal Resonator (QCR) for the Potential Diagnosis of Arthritic Diseases

1
Center for Biomedical Technology (CTB), Technical University of Madrid (UPM), 28040 Madrid, Spain
2
Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Technical University of Madrid (UPM), 28040 Madrid, Spain
3
Research and Technological Development Center of Electrical, Electronic and ICT Industry (CIDEI), 111311 Bogotá, Colombia
4
Faculty of Engineering and Basic Sciences, Central University, 111711 Bogotá, Colombia
*
Author to whom correspondence should be addressed.
Academic Editors: Eiichi Tamiya, Yuji Murakami, Tatsuro Endo and Mun’delanji Vestergaard
Received: 10 August 2016 / Revised: 30 September 2016 / Accepted: 20 October 2016 / Published: 22 November 2016
(This article belongs to the Special Issue Point-of-Care Biosensors)
View Full-Text   |   Download PDF [3495 KB, uploaded 24 November 2016]   |  

Abstract

The main objective of this article is to demonstrate through experimental means the capacity of the quartz crystal resonator (QCR) to characterize biological samples of aqueous dilutions of hyaluronic acid according to their viscosity and how this capacity may be useful in the potential diagnosis of arthritic diseases. The synovial fluid is viscous due to the presence of hyaluronic acid, synthesized by synovial lining cells (type B), and secreted into the synovial fluid thus making the fluid viscous. In consequence, aqueous dilutions of hyaluronic acid may be used as samples to emulate the synovial fluid. Due to the viscoelastic and pseudo-plastic behavior of hyaluronic acid, it is necessary to use the Rouse model in order to obtain viscosity values comparable with viscometer measures. A Fungilab viscometer (rheometer) was used to obtain reference measures of the viscosity in each sample in order to compare them with the QCR prototype measures. View Full-Text
Keywords: viscosity; non-Newtonian fluid; synovial fluid; QCR; arthritic disease viscosity; non-Newtonian fluid; synovial fluid; QCR; arthritic disease
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ahumada, L.A.C.; González, M.X.R.; Sandoval, O.L.H.; Olmedo, J.J.S. Evaluation of Hyaluronic Acid Dilutions at Different Concentrations Using a Quartz Crystal Resonator (QCR) for the Potential Diagnosis of Arthritic Diseases. Sensors 2016, 16, 1959.

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