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Sensors 2016, 16(12), 2207; doi:10.3390/s16122207

Improvement of Depth Profiling into Biotissues Using Micro Electrical Impedance Spectroscopy on a Needle with Selective Passivation

1
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, Korea
2
School of Mechanical Engineering, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Eiichi Tamiya, Yuji Murakami, Tatsuro Endo and Mun’delanji Vestergaard
Received: 9 November 2016 / Revised: 12 December 2016 / Accepted: 20 December 2016 / Published: 21 December 2016
(This article belongs to the Special Issue Point-of-Care Biosensors)
View Full-Text   |   Download PDF [2763 KB, uploaded 21 December 2016]   |  

Abstract

A micro electrical impedance spectroscopy (EIS)-on-a-needle for depth profiling (μEoN-DP) with a selective passivation layer (SPL) on a hypodermic needle was recently fabricated to measure the electrical impedance of biotissues along with the penetration depths. The SPL of the μEoN-DP enabled the sensing interdigitated electrodes (IDEs) to contribute predominantly to the measurement by reducing the relative influence of the connection lines on the sensor output. The discrimination capability of the μEoN-DP was verified using phosphate-buffered saline (PBS) at various concentration levels. The resistance and capacitance extracted through curve fitting were similar to those theoretically estimated based on the mixing ratio of PBS and deionized water; the maximum discrepancies were 8.02% and 1.85%, respectively. Depth profiling was conducted using four-layered porcine tissue to verify the effectiveness of the discrimination capability of the μEoN-DP. The magnitude and phase between dissimilar porcine tissues (fat and muscle) were clearly discriminated at the optimal frequency of 1 MHz. Two kinds of simulations, one with SPL and the other with complete passivation layer (CPL), were performed, and it was verified that the SPL was advantageous over CPL in the discrimination of biotissues in terms of sensor output. View Full-Text
Keywords: electrical impedance spectroscopy; hypodermic needle; interdigitated electrodes; selective passivation; depth profiling; biotissues electrical impedance spectroscopy; hypodermic needle; interdigitated electrodes; selective passivation; depth profiling; biotissues
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yun, J.; Kim, H.W.; Lee, J.-H. Improvement of Depth Profiling into Biotissues Using Micro Electrical Impedance Spectroscopy on a Needle with Selective Passivation. Sensors 2016, 16, 2207.

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