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Sensors 2016, 16(1), 56; doi:10.3390/s16010056

Construction of an Electrochemical Sensor Based on Carbon Nanotubes/Gold Nanoparticles for Trace Determination of Amoxicillin in Bovine Milk

1
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Selangor, Malaysia
2
Institute of Advanced Technology, Universiti Putra Malaysia, 43400 Selangor, Malaysia
*
Authors to whom correspondence should be addressed.
Academic Editor: W. Rudolf Seitz
Received: 20 November 2015 / Revised: 22 December 2015 / Accepted: 26 December 2015 / Published: 20 January 2016
(This article belongs to the Section Chemical Sensors)
View Full-Text   |   Download PDF [1873 KB, uploaded 21 January 2016]   |  

Abstract

In this work, a novel electrochemical sensor was fabricated for determination of amoxicillin in bovine milk samples by decoration of carboxylated multi-walled carbon nanotubes (MWCNTs) with gold nanoparticles (AuNPs) using ethylenediamine (en) as a cross linker (AuNPs/en-MWCNTs). The constructed nanocomposite was homogenized in dimethylformamide and drop casted on screen printed electrode. Field emission scanning electron microscopy (FESEM), energy dispersive X-Ray (EDX), X-Ray diffraction (XRD) and cyclic voltammetry were used to characterize the synthesized nanocomposites. The results show that the synthesized nanocomposites induced a remarkable synergetic effect for the oxidation of amoxicillin. Effect of some parameters, including pH, buffer, scan rate, accumulation potential, accumulation time and amount of casted nanocomposites, on the sensitivity of fabricated sensor were optimized. Under the optimum conditions, there was two linear calibration ranges from 0.2–10 µM and 10–30 µM with equations of Ipa (µA) = 2.88C (µM) + 1.2017; r = 0.9939 and Ipa (µA) = 0.88C (µM) + 22.97; r = 0.9973, respectively. The limit of detection (LOD) and limit of quantitation (LOQ) were calculated as 0.015 µM and 0.149 µM, respectively. The fabricated electrochemical sensor was successfully applied for determination of Amoxicillin in bovine milk samples and all results compared with high performance liquid chromatography (HPLC) standard method. View Full-Text
Keywords: amoxicillin; bovine milk; electrochemical sensor; MWCNTs; ethylediamine; AuNPs amoxicillin; bovine milk; electrochemical sensor; MWCNTs; ethylediamine; AuNPs
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Muhammad, A.; Yusof, N.A.; Hajian, R.; Abdullah, J. Construction of an Electrochemical Sensor Based on Carbon Nanotubes/Gold Nanoparticles for Trace Determination of Amoxicillin in Bovine Milk. Sensors 2016, 16, 56.

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