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Open AccessCommunication
Sensors 2015, 15(2), 3565-3574; doi:10.3390/s150203565

Amplification of the Signal Intensity of Fluorescence-Based Fiber-Optic Biosensors Using a Fabry-Perot Resonator Structure

1
Institute of Applied Mechanics, National Taiwan University, 1 Sec.4 Roosevelt Road, Taipei 10617, Taiwan
2
Institute of Biomedical Engineering, National Yang-Ming University, No.155, Sec.2 Linong Street, Taipei 11221, Taiwan
3
Department of Optics and Photonics, National Central University, Jhongli 32001, Taiwan
*
Author to whom correspondence should be addressed.
Received: 13 November 2014 / Revised: 19 January 2015 / Accepted: 29 January 2015 / Published: 4 February 2015
(This article belongs to the Special Issue Advances in Optical Biosensors)
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Abstract

Fluorescent biosensors have been widely used in biomedical applications. To amplify the intensity of fluorescence signals, this study developed a novel structure for an evanescent wave fiber-optic biosensor by using a Fabry-Perot resonator structure. An excitation light was coupled into the optical fiber through a laser-drilled hole on the proximal end of the resonator. After entering the resonator, the excitation light was reflected back and forth inside the resonator, thereby amplifying the intensity of the light in the fiber. Subsequently, the light was used to excite the fluorescent molecules in the reactive region of the sensor. The experimental results showed that the biosensor signal was amplified eight-fold when the resonator reflector was formed using a 92% reflective coating. Furthermore, in a simulation, the biosensor signal could be amplified 20-fold by using a 99% reflector. View Full-Text
Keywords: fiber-optic biosensor (FOBS); biosensor structure; evanescent wave; resonator; fluorescent intensity fiber-optic biosensor (FOBS); biosensor structure; evanescent wave; resonator; fluorescent intensity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hsieh, M.-C.; Chiu, Y.-H.; Lin, S.-F.; Chang, J.-Y.; Chang, C.-O.; Chiang, H.K. Amplification of the Signal Intensity of Fluorescence-Based Fiber-Optic Biosensors Using a Fabry-Perot Resonator Structure. Sensors 2015, 15, 3565-3574.

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