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Sensors 2015, 15(2), 3138-3153; doi:10.3390/s150203138

Optical Microsystem for Analysis of Diffuse Reflectance and Fluorescence Signals Applied to Early Gastrointestinal Cancer Detection

1
Department of Industrial Electronics, University of Minho, Campus de Azurém, Guimarães 4800-058, Portugal
2
Centre of Physics (CFUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 17 September 2014 / Accepted: 23 January 2015 / Published: 30 January 2015
(This article belongs to the Special Issue Advances in Optical Biosensors)
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Abstract

The detection of cancer at its earliest stage is crucial in order to increase the probability of a successful treatment. Optical techniques, specifically diffuse reflectance and fluorescence, may considerably improve the ability to detect pre-cancerous lesions. These techniques have high sensitivity to some biomarkers present on the tissues, providing morphological and biochemical information of normal and diseased tissue. The development of a chip sized spectroscopy microsystem, based on these techniques, will greatly improve the early diagnosis of gastrointestinal cancers. The main innovation is the detection of the spectroscopic signals using only few, but representative, spectral bands allowing for miniaturization. This paper presents the mathematical models, its validation and analysis for retrieving data of the measured spectroscopic signals. These models were applied to a set of phantoms clearly representative of gastrointestinal tissues, leading to a more accurate diagnostic by a pathologist. Moreover, it was demonstrated that the models can use the reconstructed spectroscopic signals based only on its extraction on those specific spectral bands. As a result, the viability of the spectroscopy microsystem implementation was proved. View Full-Text
Keywords: optical microsystem; gastrointestinal cancer; early diagnostic; diffuse reflectance; fluorescence; mathematical models optical microsystem; gastrointestinal cancer; early diagnostic; diffuse reflectance; fluorescence; mathematical models
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pimenta, S.; Castanheira, E.M.S.; Minas, G. Optical Microsystem for Analysis of Diffuse Reflectance and Fluorescence Signals Applied to Early Gastrointestinal Cancer Detection. Sensors 2015, 15, 3138-3153.

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