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Sensors 2015, 15(1), 1564-1600; doi:10.3390/s150101564

Functionalized Solid Electrodes for Electrochemical Biosensing of Purine Nucleobases and Their Analogues: A Review

1
Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, CZ–625 00 Brno, Czech Republic
2
Institute of Biophysics of the Academy of Sciences of the Czech Republic, V.V.I., Kralovopolska 135, CZ–612 65 Brno, Czech Republic
3
SIX Research Centre, University of Technology Brno, Technicka 3058/10, CZ–616 00 Brno, Czech Republic
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 27 November 2014 / Accepted: 4 January 2015 / Published: 14 January 2015
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Abstract

Interest in electrochemical analysis of purine nucleobases and few other important purine derivatives has been growing rapidly. Over the period of the past decade, the design of electrochemical biosensors has been focused on achieving high sensitivity and efficiency. The range of existing electrochemical methods with carbon electrode displays the highest rate in the development of biosensors. Moreover, modification of electrode surfaces based on nanomaterials is frequently used due to their extraordinary conductivity and surface to volume ratio. Different strategies for modifying electrode surfaces facilitate electron transport between the electrode surface and biomolecules, including DNA, oligonucleotides and their components. This review aims to summarize recent developments in the electrochemical analysis of purine derivatives, as well as discuss different applications. View Full-Text
Keywords: purine derivatives; electrochemistry of purines; carbon electrode; gold electrode; platinum electrode; indium tin oxide electrode; boron doped electrode; modified electrodes purine derivatives; electrochemistry of purines; carbon electrode; gold electrode; platinum electrode; indium tin oxide electrode; boron doped electrode; modified electrodes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sharma, V.K.; Jelen, F.; Trnkova, L. Functionalized Solid Electrodes for Electrochemical Biosensing of Purine Nucleobases and Their Analogues: A Review. Sensors 2015, 15, 1564-1600.

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