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Sensors 2013, 13(4), 4170-4191; doi:10.3390/s130404170

Quantitative Phase Imaging Techniques for the Study of Cell Pathophysiology: From Principles to Applications

1
Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
2
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
3
Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
4
Hankuk Academy of Foreign Studies, Yongin 449-854, Korea
*
Author to whom correspondence should be addressed.
Received: 19 February 2013 / Revised: 11 March 2013 / Accepted: 18 March 2013 / Published: 28 March 2013
(This article belongs to the Special Issue Medical & Biological Imaging)
View Full-Text   |   Download PDF [689 KB, 21 June 2014; original version 21 June 2014]   |  

Abstract

A cellular-level study of the pathophysiology is crucial for understanding the mechanisms behind human diseases. Recent advances in quantitative phase imaging (QPI) techniques show promises for the cellular-level understanding of the pathophysiology of diseases. To provide important insight on how the QPI techniques potentially improve the study of cell pathophysiology, here we present the principles of QPI and highlight some of the recent applications of QPI ranging from cell homeostasis to infectious diseases and cancer.
Keywords: microscopy; optical imaging; bio-photonics; quantitative phase imaging; cell physiology microscopy; optical imaging; bio-photonics; quantitative phase imaging; cell physiology
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lee, K.; Kim, K.; Jung, J.; Heo, J.; Cho, S.; Lee, S.; Chang, G.; Jo, Y.; Park, H.; Park, Y. Quantitative Phase Imaging Techniques for the Study of Cell Pathophysiology: From Principles to Applications. Sensors 2013, 13, 4170-4191.

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