Sensors 2013, 13(4), 4041-4050; doi:10.3390/s130404041
Article

Evaluation of Moisture-Related Attenuation Coefficient and Water Diffusion Velocity in Human Skin Using Optical Coherence Tomography

1 Department of Electrical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 33302, Taiwan 2 Graduate Institute of Medical Mechatronics, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 33302, Taiwan 3 Department of Dermatology, Chang Gung Memorial Hospital, 5 Fusing Street, Kwei-Shan, Tao-Yaun 33302, Taiwan 4 Department of Ophthalmology, Chang Gung Memorial Hospital, 5 Fusing Street, Kwei-Shan, Tao-Yaun 33302, Taiwan
* Author to whom correspondence should be addressed.
Received: 24 January 2013; in revised form: 9 March 2013 / Accepted: 20 March 2013 / Published: 25 March 2013
(This article belongs to the Special Issue Medical & Biological Imaging)
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Abstract: In this study, time-resolved optical coherence tomography (OCT) scanning images of the process of water diffusion in the skin that illustrate the enhancement in the backscattered intensities due to the increased water concentration are presented. In our experiments, the water concentration in the skin was increased by soaking the hand in water, and the same region of the skin was scanned and measured with the OCT system and a commercial moisture monitor every three minutes. To quantitatively analyze the moisture-related optical properties and the velocity of water diffusion in human skin, the attenuation coefficients of the skin, including the epidermis and dermis layers, were evaluated. Furthermore, the evaluated attenuation coefficients were compared with the measurements made using the commercial moisture monitor. The results demonstrate that the attenuation coefficient increases as the water concentration increases. Furthermore, by evaluating the positions of center-of mass of the backscattered intensities from OCT images, the diffusion velocity can be estimated. In contrast to the commercial moisture monitor, OCT can provide three-dimensional structural images of the skin and characterize its optical property, which together can be used to observe morphological changes and quantitatively evaluate the moisture-related attenuation coefficients in different skin layers.
Keywords: optical coherence tomography; moisture; attenuation coefficient; water diffusion

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MDPI and ACS Style

Lee, C.-K.; Tsai, M.-T.; Chang, F.-Y.; Yang, C.-H.; Shen, S.-C.; Yuan, O.; Yang, C.-H. Evaluation of Moisture-Related Attenuation Coefficient and Water Diffusion Velocity in Human Skin Using Optical Coherence Tomography. Sensors 2013, 13, 4041-4050.

AMA Style

Lee C-K, Tsai M-T, Chang F-Y, Yang C-H, Shen S-C, Yuan O, Yang C-H. Evaluation of Moisture-Related Attenuation Coefficient and Water Diffusion Velocity in Human Skin Using Optical Coherence Tomography. Sensors. 2013; 13(4):4041-4050.

Chicago/Turabian Style

Lee, Cheng-Kuang; Tsai, Meng-Tsan; Chang, Feng-Yu; Yang, Chih-Hsun; Shen, Su-Chin; Yuan, Ouyang; Yang, Chih-He. 2013. "Evaluation of Moisture-Related Attenuation Coefficient and Water Diffusion Velocity in Human Skin Using Optical Coherence Tomography." Sensors 13, no. 4: 4041-4050.

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