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Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation
School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia
Storr Liver Unit, at the Westmead Millennium Institute, The University of Sydney at the Westmead Hospital, Westmead NSW 2145, Australia
School of Medical Science and Griffith Health Institute, Griffith University, Gold Coast Campus, Southport 4222, Australia
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33612, USA
Suzhou Key Laboratory of Nanobiomedicine, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, China
Institute for Frontier Materials, Deakin University, Waurn Ponds, Victoria 3217, Australia
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India
Centre for Complimentary Medicine Research, National Institute of Complementary Medicine, University of Western Sydney, Campbelltown Campus, Penrith, NSW 2751, Australia
* Authors to whom correspondence should be addressed.
Received: 7 August 2013; in revised form: 24 September 2013 / Accepted: 27 September 2013 / Published: 10 October 2013
(This article belongs to the Special Issue Aptasensors
Abstract: Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
Keywords: aptamer; SELEX; cancer; diagnostics; locked nucleic acid; unlocked nucleic acid
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Shigdar, S.; Macdonald, J.; O'Connor, M.; Wang, T.; Xiang, D.; Al.Shamaileh, H.; Qiao, L.; Wei, M.; Zhou, S.-F.; Zhu, Y.; Kong, L.; Bhattacharya, S.; Li, C.; Duan, W. Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation. Sensors 2013, 13, 13624-13637.
Shigdar S, Macdonald J, O'Connor M, Wang T, Xiang D, Al.Shamaileh H, Qiao L, Wei M, Zhou S-F, Zhu Y, Kong L, Bhattacharya S, Li C, Duan W. Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation. Sensors. 2013; 13(10):13624-13637.
Shigdar, Sarah; Macdonald, Joanna; O'Connor, Michael; Wang, Tao; Xiang, Dongxi; Al.Shamaileh, Hadi; Qiao, Liang; Wei, Ming; Zhou, Shu-Feng; Zhu, Yimin; Kong, Lingxue; Bhattacharya, Santanu; Li, ChunGuang; Duan, Wei. 2013. "Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation." Sensors 13, no. 10: 13624-13637.