Sensors 2013, 13(10), 13624-13637; doi:10.3390/s131013624
Review

Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

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Received: 7 August 2013; in revised form: 24 September 2013 / Accepted: 27 September 2013 / Published: 10 October 2013
(This article belongs to the Special Issue Aptasensors)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
Keywords: aptamer; SELEX; cancer; diagnostics; locked nucleic acid; unlocked nucleic acid
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MDPI and ACS Style

Shigdar, S.; Macdonald, J.; O'Connor, M.; Wang, T.; Xiang, D.; Al.Shamaileh, H.; Qiao, L.; Wei, M.; Zhou, S.-F.; Zhu, Y.; Kong, L.; Bhattacharya, S.; Li, C.; Duan, W. Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation. Sensors 2013, 13, 13624-13637.

AMA Style

Shigdar S, Macdonald J, O'Connor M, Wang T, Xiang D, Al.Shamaileh H, Qiao L, Wei M, Zhou S-F, Zhu Y, Kong L, Bhattacharya S, Li C, Duan W. Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation. Sensors. 2013; 13(10):13624-13637.

Chicago/Turabian Style

Shigdar, Sarah; Macdonald, Joanna; O'Connor, Michael; Wang, Tao; Xiang, Dongxi; Al.Shamaileh, Hadi; Qiao, Liang; Wei, Ming; Zhou, Shu-Feng; Zhu, Yimin; Kong, Lingxue; Bhattacharya, Santanu; Li, ChunGuang; Duan, Wei. 2013. "Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation." Sensors 13, no. 10: 13624-13637.


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