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Protein Biosensors Based on Polymer Nanowires, Carbon Nanotubes and Zinc Oxide Nanorods
Microelectronics Photonics, University of Arkansas, Fayetteville, AR 72701, USA
Department of Electrical Engineering, University of Arkansas, Fayetteville, AR 72701, USA
* Author to whom correspondence should be addressed.
Received: 13 April 2011; in revised form: 3 May 2011 / Accepted: 5 May 2011 / Published: 9 May 2011
Abstract: The development of biosensors using electrochemical methods is a promising application in the field of biotechnology. High sensitivity sensors for the bio-detection of proteins have been developed using several kinds of nanomaterials. The performance of the sensors depends on the type of nanostructures with which the biomaterials interact. One dimensional (1-D) structures such as nanowires, nanotubes and nanorods are proven to have high potential for bio-applications. In this paper we review these three different kinds of nanostructures that have attracted much attention at recent times with their great performance as biosensors. Materials such as polymers, carbon and zinc oxide have been widely used for the fabrication of nanostructures because of their enhanced performance in terms of sensitivity, biocompatibility, and ease of preparation. Thus we consider polymer nanowires, carbon nanotubes and zinc oxide nanorods for discussion in this paper. We consider three stages in the development of biosensors: (a) fabrication of biomaterials into nanostructures, (b) alignment of the nanostructures and (c) immobilization of proteins. Two different methods by which the biosensors can be developed at each stage for all the three nanostructures are examined. Finally, we conclude by mentioning some of the major challenges faced by many researchers who seek to fabricate biosensors for real time applications.
Keywords: biosensor; nanostructures; electrochemical; immobilization
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MDPI and ACS Style
Kumar M., A.; Jung, S.; Ji, T. Protein Biosensors Based on Polymer Nanowires, Carbon Nanotubes and Zinc Oxide Nanorods. Sensors 2011, 11, 5087-5111.
Kumar M. A, Jung S, Ji T. Protein Biosensors Based on Polymer Nanowires, Carbon Nanotubes and Zinc Oxide Nanorods. Sensors. 2011; 11(5):5087-5111.
Kumar M., Anish; Jung, Soyoun; Ji, Taeksoo. 2011. "Protein Biosensors Based on Polymer Nanowires, Carbon Nanotubes and Zinc Oxide Nanorods." Sensors 11, no. 5: 5087-5111.