A Conductometric Indium Oxide Semiconducting Nanoparticle Enzymatic Biosensor Array
AbstractWe report a conductometric nanoparticle biosensor array to address the significant variation of electrical property in nanomaterial biosensors due to the random network nature of nanoparticle thin-film. Indium oxide and silica nanoparticles (SNP) are assembled selectively on the multi-site channel area of the resistors using layer-by-layer self-assembly. To demonstrate enzymatic biosensing capability, glucose oxidase is immobilized on the SNP layer for glucose detection. The packaged sensor chip onto a ceramic pin grid array is tested using syringe pump driven feed and multi-channel I–V measurement system. It is successfully demonstrated that glucose is detected in many different sensing sites within a chip, leading to concentration dependent currents. The sensitivity has been found to be dependent on the channel length of the resistor, 4–12 nA/mM for channel lengths of 5–20 µm, while the apparent Michaelis-Menten constant is 20 mM. By using sensor array, analytical data could be obtained with a single step of sample solution feeding. This work sheds light on the applicability of the developed nanoparticle microsensor array to multi-analyte sensors, novel bioassay platforms, and sensing components in a lab-on-a-chip.
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Lee, D.; Ondrake, J.; Cui, T. A Conductometric Indium Oxide Semiconducting Nanoparticle Enzymatic Biosensor Array. Sensors 2011, 11, 9300-9312.
Lee D, Ondrake J, Cui T. A Conductometric Indium Oxide Semiconducting Nanoparticle Enzymatic Biosensor Array. Sensors. 2011; 11(10):9300-9312.Chicago/Turabian Style
Lee, Dongjin; Ondrake, Janet; Cui, Tianhong. 2011. "A Conductometric Indium Oxide Semiconducting Nanoparticle Enzymatic Biosensor Array." Sensors 11, no. 10: 9300-9312.