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Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions
Fujirebio, Fujirebio, Inc., 51 Komiya-cho, Hachioji-shi 192-0031, Tokyo, Japan
nanoBioAnalytics, Schwarzschildstr. 8, 12489 Berlin, Germany
Institute of Materials Research and Engineering, 3, Research Link, 117602, Singapore
Centre of Expertise in Photonics, School of Chemistry and Physics, The University of Adelaide, SA5005, Australia
* Author to whom correspondence should be addressed.
Received: 8 January 2010; in revised form: 12 March 2010 / Accepted: 9 June 2010 / Published: 22 June 2010
Abstract: Whispering gallery modes (WGMs) in surface-fixated fluorescent polystyrene microbeads are studied in view of their capability of sensing the formation of biochemical adsorption layers on their outer surface with the well-established biotin-streptavidin specific binding as the model system. Three different methods for analysis of the observed shifts in the WGM wavelength positions are applied and used to quantify the adsorbed mass densities, which are then compared with the results of a comparative surface plasmon resonance (SPR) study.
Keywords: whispering gallery modes; cavity modes; optical sensing; refractive index sensing; biosensing; label-free detection
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MDPI and ACS Style
Himmelhaus, M.; Krishnamoorthy, S.; Francois, A. Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions. Sensors 2010, 10, 6257-6274.
Himmelhaus M, Krishnamoorthy S, Francois A. Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions. Sensors. 2010; 10(6):6257-6274.
Himmelhaus, Michael; Krishnamoorthy, Sivashankar; Francois, Alexandre. 2010. "Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions." Sensors 10, no. 6: 6257-6274.