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Sensors 2010, 10(6), 6257-6274; doi:10.3390/s100606257
Article

Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions

1,2,* , 1,3
 and 1,4
1 Fujirebio, Fujirebio, Inc., 51 Komiya-cho, Hachioji-shi 192-0031, Tokyo, Japan 2 nanoBioAnalytics, Schwarzschildstr. 8, 12489 Berlin, Germany 3 Institute of Materials Research and Engineering, 3, Research Link, 117602, Singapore 4 Centre of Expertise in Photonics, School of Chemistry and Physics, The University of Adelaide, SA5005, Australia
* Author to whom correspondence should be addressed.
Received: 8 January 2010 / Revised: 12 March 2010 / Accepted: 9 June 2010 / Published: 22 June 2010
(This article belongs to the Section Biosensors)
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Abstract

Whispering gallery modes (WGMs) in surface-fixated fluorescent polystyrene microbeads are studied in view of their capability of sensing the formation of biochemical adsorption layers on their outer surface with the well-established biotin-streptavidin specific binding as the model system. Three different methods for analysis of the observed shifts in the WGM wavelength positions are applied and used to quantify the adsorbed mass densities, which are then compared with the results of a comparative surface plasmon resonance (SPR) study.
Keywords: whispering gallery modes; cavity modes; optical sensing; refractive index sensing; biosensing; label-free detection whispering gallery modes; cavity modes; optical sensing; refractive index sensing; biosensing; label-free detection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Himmelhaus, M.; Krishnamoorthy, S.; Francois, A. Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions. Sensors 2010, 10, 6257-6274.

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