- freely available
The Role of PAS Kinase in PASsing the Glucose Signal
AbstractPAS kinase is an evolutionarily conserved nutrient responsive protein kinase that regulates glucose homeostasis. Mammalian PAS kinase is activated by glucose in pancreatic beta cells, and knockout mice are protected from obesity, liver triglyceride accumulation, and insulin resistance when fed a high-fat diet. Yeast PAS kinase is regulated by both carbon source and cell integrity stress and stimulates the partitioning of glucose toward structural carbohydrate biosynthesis. In our current model for PAS kinase regulation, a small molecule metabolite binds the sensory PAS domain and activates the enzyme. Although bona fide PAS kinase substrates are scarce, in vitro substrate searches provide putative targets for exploration.
Share & Cite This Article
Grose, J.H.; Rutter, J. The Role of PAS Kinase in PASsing the Glucose Signal. Sensors 2010, 10, 5668-5682.View more citation formats
Grose JH, Rutter J. The Role of PAS Kinase in PASsing the Glucose Signal. Sensors. 2010; 10(6):5668-5682.Chicago/Turabian Style
Grose, Julianne H.; Rutter, Jared. 2010. "The Role of PAS Kinase in PASsing the Glucose Signal." Sensors 10, no. 6: 5668-5682.