A Nutritional Approach for the Management of Deoxynivalenol (DON) Toxicity in the Gastrointestinal Tract of Growing Chickens
Abstract
:1. Introduction
2. Materials and Methods
2.1. Birds and feeding
2.2. Tissue preparation
2.3. Isolated intestinal tissues in using chambers
2.4. Statistics
3. Results
3.1. Effect of DON addition after glucose addition on tissue resistance and short-circuit current
3.2. Effect of D-glucose addition on tissue resistance and short-circuit current after preincubation of the tissues with DON
4. Discussion
5. Conclusions
References
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Ingredients | Composition |
---|---|
Maize | 50.50 |
Soya meal | 30.00 |
Wheat | 10.00 |
Potato Protein | 3.00 |
Soya oil | 1.40 |
Sodium chloride | 0.10 |
Vitamin-Mineral Mixture1 | 5.00 |
Analysed composition (DM) | |
Dry matter (%) | 87.9 |
Ash (%) | 6.6 |
Crude fiber (%) | 1.5 |
Crude protein (%) | 24.9 |
Crude fat (%) | 3.5 |
Calculated ME (kcal/kg) | 2,820 |
Calcium (%) | 1.08 |
Phosphorous (%) | 0.87 |
Magnesium (%) | 0.26 |
Sodium (%) | 0.33 |
Potassium (%) | 1.27 |
Parameters /Organs | Groups
| SEM | P value | |
---|---|---|---|---|
Control | Inulin | |||
1- Jejunum | ||||
Basal Isc (μA/cm2) | 32b | 7b | 8 | 0.203 |
Isc after glucose addition (μA/cm2) | 53a | 33a | 7 | 0.135 |
Isc after DON addition (μA/cm2) | 3b | 3b | 7 | 0.974 |
2- Colon | ||||
Basal Isc (μA/cm2) | −32b | −5b | 17 | 0.234 |
Isc after glucose addition (μA/cm2) | −2a | 30a | 11 | 0.241 |
Isc after DON addition (μA/cm2) | −63b | −5b* | 20 | 0.083 |
Parameters /Organs | Groups
| SEM | P value | |
---|---|---|---|---|
Control | Inulin | |||
1- Jejunum | ||||
Basal Rt (Ohm.cm2) | 342b | 330 | 36 | 0.477 |
Rt after glucose addition (Ohm.cm2) | 360b | 336 | 38 | 0.186 |
Rt after DON addition (Ohm.cm2) | 423a* | 369 | 47 | 0.070 |
2- Colon | ||||
Basal Rt (Ohm.cm2) | 160 | 148 | 6 | 0.275 |
Rt after glucose addition (Ohm.cm2) | 144 | 123 | 8 | 0.148 |
Rt after DON addition (Ohm.cm2) | 139 | 127 | 6 | 0.284 |
Parameters /tissue | Groups
| SEM | P value | |
---|---|---|---|---|
Control | Inulin | |||
Jejunum | ||||
Basal Isc with DON (μA/cm2) | −7 | 3b | 6 | 0.421 |
Isc after glucose addition (μA/cm2) | −7 | 6a | 6 | 0.233 |
Colon | ||||
Basal Isc with DON (μA/cm2) | 14 | −40b | 25 | 0.318 |
Isc after glucose addition (μA/cm2) | −3 | 69a | 34 | 0.330 |
Parameters /tissue | Groups
| SEM | P value | |
---|---|---|---|---|
Control | Inulin | |||
Jejunum | ||||
Basal Rt with DON (Ω·cm2) | 320b | 378 | 33 | 0.088 |
Rt after glucose addition (Ω cm2) | 374a | 391 | 32 | 0.212 |
Colon | ||||
Basal Rt with DON (Ω cm2) | 166 | 145 | 11 | 0.380 |
Rt after glucose addition (Ω cm2) | 135 | 128 | 8 | 0.688 |
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/). This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).
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Awad, W.; Ghareeb, K.; Böhm, J.; Zentek, J. A Nutritional Approach for the Management of Deoxynivalenol (DON) Toxicity in the Gastrointestinal Tract of Growing Chickens. Int. J. Mol. Sci. 2008, 9, 2505-2514. https://doi.org/10.3390/ijms9122505
Awad W, Ghareeb K, Böhm J, Zentek J. A Nutritional Approach for the Management of Deoxynivalenol (DON) Toxicity in the Gastrointestinal Tract of Growing Chickens. International Journal of Molecular Sciences. 2008; 9(12):2505-2514. https://doi.org/10.3390/ijms9122505
Chicago/Turabian StyleAwad, Wageha, Khaled Ghareeb, Josef Böhm, and Jürgen Zentek. 2008. "A Nutritional Approach for the Management of Deoxynivalenol (DON) Toxicity in the Gastrointestinal Tract of Growing Chickens" International Journal of Molecular Sciences 9, no. 12: 2505-2514. https://doi.org/10.3390/ijms9122505