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Int. J. Mol. Sci. 2017, 18(8), 1647; doi:10.3390/ijms18081647

The HGF/SF Mouse Model of UV-Induced Melanoma as an In Vivo Sensor for Metastasis-Regulating Gene

1
Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland-Baltimore, Baltimore, MD 21201, USA
2
University of Maryland Greenebaum Comprehensive Cancer Center, University of Maryland-Baltimore, Baltimore, MD 21201, USA
3
Department of Dermatology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35249, USA
4
Cancer Chemoprevention Program, and Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL 35249, USA
5
Pathology and Laboratory Medicine Service, VA Medical Center, Birmingham, AL 35249, USA
*
Author to whom correspondence should be addressed.
Received: 12 June 2017 / Revised: 19 July 2017 / Accepted: 24 July 2017 / Published: 28 July 2017
(This article belongs to the Special Issue Animal Models of Melanoma)
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Abstract

Cutaneous malignant melanoma is an aggressive and potentially lethal form of skin cancer, particularly in its advanced and therapy-resistant stages, and the need for novel therapeutics and prognostic tools is acute. Incidence of melanoma has steadily increased over the past few decades, with exposure to the genome-damaging effects of ultraviolet radiation (UVR) well-recognized as a primary cause. A number of genetically-engineered mouse models (GEMMs) have been created that exhibit high incidence of spontaneous and induced forms of melanoma, and a select subset recapitulates its progression to aggressive and metastatic forms. These GEMMs hold considerable promise for providing insights into advanced stages of melanoma, such as potential therapeutic targets and prognostic markers, and as in vivo systems for testing of novel therapies. In this review, we summarize how the HGF/SF transgenic mouse has been used to reveal metastasis-regulating activity of four different genes (CDK4R24C, survivin and NME1/NME2) in the context of UV-induced melanoma. We also discuss how these models can potentially yield new strategies for clinical management of melanoma in its most aggressive forms. View Full-Text
Keywords: HGF; melanoma; metastasis; genetically engineered mouse models HGF; melanoma; metastasis; genetically engineered mouse models
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Leonard, M.K.; Pamidimukkala, N.; Puts, G.S.; Snyder, D.E.; Slominski, A.T.; Kaetzel, D.M. The HGF/SF Mouse Model of UV-Induced Melanoma as an In Vivo Sensor for Metastasis-Regulating Gene. Int. J. Mol. Sci. 2017, 18, 1647.

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