Next Article in Journal
Reprimo, a Potential p53-Dependent Tumor Suppressor Gene, Is Frequently Hypermethylated in Estrogen Receptor α-Positive Breast Cancer
Next Article in Special Issue
Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma
Previous Article in Journal
The Mechanistic Links between Insulin and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl Channel
Previous Article in Special Issue
The HGF/SF Mouse Model of UV-Induced Melanoma as an In Vivo Sensor for Metastasis-Regulating Gene
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessCase Report
Int. J. Mol. Sci. 2017, 18(8), 1769; doi:10.3390/ijms18081769

Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus

1
Departments of Dermatology and Pathology, University of Alabama at Birmingham, Birmingham, AL 35201, USA
2
Department of Dermatopathology, Albany Medical College, Albany, NY 12201, USA
3
Department of Biochemistry and Molecular Biology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
4
Center for Cancer Research, National Cancer Institute, Bethesda, MD 21201, USA
5
Veterans Affairs Medical Center, Birmingham, AL 35201, USA
Abstract Presented during the Poster Session at the American Society of Dermatopathology (ASDP) 2015 Annual Meeting, October, 2015, San Francisco, CA 94101, USA.
*
Author to whom correspondence should be addressed.
Received: 25 July 2017 / Revised: 8 August 2017 / Accepted: 10 August 2017 / Published: 15 August 2017
(This article belongs to the Special Issue Animal Models of Melanoma)
View Full-Text   |   Download PDF [7531 KB, uploaded 15 August 2017]   |  

Abstract

Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with infiltrative borders, however, their origin remains unclear. Stem cells for the epidermis and hair follicle are located in the bulge area of the hair follicle with the potential to differentiate into multiple lineages. Multiple cutaneous carcinomas, including follicular cutaneous squamous cell carcinoma (FSCC), are thought to arise from stem cells in the follicular bulge. We present two cases of PEM/ATM in a 63 year-old male on the scalp with follicular origin and a 72 year-old female on the upper back arising in an intradermal nevus. Biopsy of both cases revealed a proliferation of heavily pigmented dermal nests of melanocytes with atypia. The Case 1 tumor was in continuation with the outer root sheath of the hair follicle in the bulge region. Case 2 arose in an intradermal melanocytic nevus. Rare mitotic figures, including atypical mitotic figures, were identified in both cases. We present two cases of PEM, with histologic evidence suggesting two origins: one from the follicular bulb and one from an intradermal nevus. View Full-Text
Keywords: melanocytes; melanoma; hair follicle; hair follicle stem cell; melanin pigment melanocytes; melanoma; hair follicle; hair follicle stem cell; melanin pigment
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tarasen, A.; Carlson, J.A.; Leonard, M.K.; Merlino, G.; Kaetzel, D.; Slominski, A.T. Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus. Int. J. Mol. Sci. 2017, 18, 1769.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top