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Int. J. Mol. Sci. 2017, 18(6), 1282; doi:10.3390/ijms18061282

Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying

1
Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Seta-Otsu 520-2192, Shiga, Japan
2
Nishiwaki Laboratory, Cimic Biopharma Corporation, Nishiwaki 677-0032, Hyogo, Japan
3
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Minato-ku 108-8477, Tokyo, Japan
*
Author to whom correspondence should be addressed.
Received: 21 April 2017 / Revised: 7 June 2017 / Accepted: 13 June 2017 / Published: 16 June 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Postprandial hypertriglyceridemia is a potential target for cardiovascular disease prevention in patients with diabetic dyslipidemia. Metformin has been reported to reduce plasma triglyceride concentrations in the postprandial states. However, little is known about the mechanisms underlying the triglyceride-lowering effect of metformin. Here, we examined the effects of metformin on lipid metabolism after olive oil-loading in 129S mice fed a high fat diet for three weeks. Metformin administration (250 mg/kg) for one week decreased postprandial plasma triglycerides. Pre-administration (250 mg/kg) of metformin resulted in a stronger triglyceride-lowering effect (approximately 45% lower area under the curve) than post-administration. A single administration (250 mg/kg) of metformin lowered plasma postprandial triglycerides comparably to administration for one week, suggesting an acute effect of metformin on postprandial hypertriglyceridemia. To explore whole body lipid metabolism after fat-loading, stomach size, fat absorption in the intestine, and fat oxidation (13C/12C ratio in expired CO2 after administration of glyceryl-1-13C tripalmitate) were measured with and without metformin (250 mg/kg) pre-treatment. In metformin-treated mice, larger stomach size, lower fat oxidation, and no change in lipid absorption were observed. In conclusion, metformin administration before fat loading reduced postprandial hypertriglyceridemia, most likely by delaying gastric emptying. View Full-Text
Keywords: Metformin; postprandial hypertriglyceridemia; gastric emptying Metformin; postprandial hypertriglyceridemia; gastric emptying
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sato, D.; Morino, K.; Nakagawa, F.; Murata, K.; Sekine, O.; Beppu, F.; Gotoh, N.; Ugi, S.; Maegawa, H. Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying. Int. J. Mol. Sci. 2017, 18, 1282.

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