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Int. J. Mol. Sci. 2017, 18(6), 1185; doi:10.3390/ijms18061185

Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration

1
Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907, USA
2
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
3
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine Lafayette, 625 Harrison Street, West Lafayette, IN 47907, USA
4
Purdue Institute for Integrative neuroscience, 610 Purdue Mall, Purdue University, West Lafayette, IN 47907, USA
5
Purdue Institute for Drug Discovery, 610 Purdue Mall, Purdue University, West Lafayette, IN 47907, USA
6
Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou 515041, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Juliette Legler
Received: 18 February 2017 / Revised: 14 May 2017 / Accepted: 16 May 2017 / Published: 2 June 2017
(This article belongs to the Special Issue Zebrafish: A Model for Toxicological Research)
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Abstract

Zebrafish are a popular vertebrate model in drug discovery. They produce a large number of small and rapidly-developing embryos. These embryos display rich visual-behaviors that can be used to screen drugs for treating retinal degeneration (RD). RD comprises blinding diseases such as Retinitis Pigmentosa, which affects 1 in 4000 people. This disease has no definitive cure, emphasizing an urgency to identify new drugs. In this review, we will discuss advantages, challenges, and research developments in using zebrafish behaviors to screen drugs in vivo. We will specifically discuss a visual-motor response that can potentially expedite discovery of new RD drugs.
Keywords: zebrafish; visual behaviors; visual motor response; drug screening; retinal degeneration; retinitis pigmentosa; night blindness zebrafish; visual behaviors; visual motor response; drug screening; retinal degeneration; retinitis pigmentosa; night blindness
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MDPI and ACS Style

Ganzen, L.; Venkatraman, P.; Pang, C.P.; Leung, Y.F.; Zhang, M. Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration. Int. J. Mol. Sci. 2017, 18, 1185.

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