Next Article in Journal
Rutin-Enriched Extract from Coriandrum sativum L. Ameliorates Ionizing Radiation-Induced Hematopoietic Injury
Next Article in Special Issue
Applying Unconventional Secretion in Ustilago maydis for the Export of Functional Nanobodies
Previous Article in Journal
CIK Cells and HDAC Inhibitors in Multiple Myeloma
Previous Article in Special Issue
Annexins as Overlooked Regulators of Membrane Trafficking in Plant Cells
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(5), 946; doi:10.3390/ijms18050946

Unconventional Secretion of Heat Shock Proteins in Cancer

International Research Center, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: Gian-Pietro Di Sansebastiano and Antonio Gaballo
Received: 10 March 2017 / Revised: 25 April 2017 / Accepted: 27 April 2017 / Published: 29 April 2017
(This article belongs to the Special Issue Unconventional Proteins and Membranes Traffic)
View Full-Text   |   Download PDF [955 KB, uploaded 5 May 2017]   |  

Abstract

Heat shock proteins (HSPs) are abundant cellular proteins involved with protein homeostasis. They have both constitutive and inducible isoforms, whose expression levels are further increased by stress conditions, such as temperature elevation, reduced oxygen levels, infection, inflammation and exposure to toxic substances. In these situations, HSPs exert a pivotal role in offering protection, preventing cell death and promoting cell recovery. Although the majority of HSPs functions are exerted in the cytoplasm and organelles, several lines of evidence reveal that HSPs are able to induce cell responses in the extracellular milieu. HSPs do not possess secretion signal peptides, and their secretion was subject to widespread skepticism until the demonstration of the role of unconventional secretion forms such as exosomes. Secretion of HSPs may confer immune system modulation and be a cell-to-cell mediated form of increasing stress resistance. Thus, there is a wide potential for secreted HSPs in resistance of cancer therapy and in the development new therapeutic strategies. View Full-Text
Keywords: heat shock proteins; cancer; unconventional secretion; exosomes heat shock proteins; cancer; unconventional secretion; exosomes
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Santos, T.G.; Martins, V.R.; Hajj, G.N.M. Unconventional Secretion of Heat Shock Proteins in Cancer. Int. J. Mol. Sci. 2017, 18, 946.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top