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Int. J. Mol. Sci. 2017, 18(5), 945; doi:10.3390/ijms18050945

CIK Cells and HDAC Inhibitors in Multiple Myeloma

1
Department of Internal Medicine III, Center for Integrated Oncology (CIO), University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Straße 25, 53105 Bonn, Germany
2
Hochschule Bonn-Rhein-Sieg, Von-Liebig-Straße 20, 53359 Rheinbach, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Michael R. Hamblin
Received: 8 February 2017 / Revised: 7 April 2017 / Accepted: 25 April 2017 / Published: 29 April 2017
(This article belongs to the Special Issue Natural Killer T (NKT) Cells)
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Abstract

Multiple myeloma is the second most common hematological malignancy. Despite all the progress made in treating multiple myeloma, it still remains an incurable disease. Patients are left with a median survival of 4–5 years. The combined treatment of multiple myeloma with histone deacetylase inhibitors and cytokine-induced killer cells provides a promising targeted treatment option for patients. This study investigated the impact of a combined treatment compared to treatment with histone deacetylase inhibitors. The experiments revealed that a treatment with histone deacetylase (HDAC) inhibitors could reduce cell viability to 59% for KMS 18 cell line and 46% for the U-266 cell line. The combined treatment led to a decrease of cell viability to 33% for KMS 18 and 27% for the U-266 cell line, thus showing a significantly better efficacy than the single treatment. View Full-Text
Keywords: multiple myeloma; cytokine-induced killer cells; CIK cells; histone deacetylase inhibitors; immunotherapy; cancer treatment multiple myeloma; cytokine-induced killer cells; CIK cells; histone deacetylase inhibitors; immunotherapy; cancer treatment
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Stephan, D.; Weiher, H.; Schmidt-Wolf, I.G. CIK Cells and HDAC Inhibitors in Multiple Myeloma. Int. J. Mol. Sci. 2017, 18, 945.

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