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Int. J. Mol. Sci. 2016, 17(7), 1151; doi:10.3390/ijms17071151

A Mini-Review for Cancer Immunotherapy: Molecular Understanding of PD-1/PD-L1 Pathway & Translational Blockade of Immune Checkpoints

1,2,3,†
,
2,3,4,†
,
1,2,3,4,5
,
1,2,3,6
,
1,2,3
,
1,2,3,4,* and 1,2,3,4,*
1
Institute of Precision Medicine and Innovative Drug Discovery, Institute of Science and Technology, Hong Kong Baptist University, Haimen 226133, China
2
Institute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong, China
3
Institute of Research and Continuing Education, Hong Kong Baptist University, Hong Kong, China
4
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
5
Faculty of Materials Science and Chemical Engineering, The State Key Laboratory Base of Novel Functional Materials and Preparation Science, Ningbo University, Ningbo 315211, China
6
College of Medicine, Jiaxing University, Jiaxing 314001, China
These authors contributed equally to this work
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 16 May 2016 / Revised: 27 June 2016 / Accepted: 7 July 2016 / Published: 18 July 2016
(This article belongs to the Collection Advances in Molecular Oncology)
View Full-Text   |   Download PDF [903 KB, uploaded 18 July 2016]   |  

Abstract

Interference of the binding of programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) has become a new inspiring immunotherapy for resisting cancers. To date, the FDA has approved two PD-1 monoclonal antibody drugs against cancer as well as a monoclonal antibody for PD-L1. More PD-1 and PD-L1 monoclonal antibody drugs are on their way in clinical trials. In this review, we focused on the mechanism of the PD-1/PD-L1 signaling pathway and the monoclonal antibodies (mAbs) against PD-1 and PD-L1, which were approved by the FDA or are still in clinical trials. And also presented is the prospect of the PD-1/PD-L1 immune checkpoint blockade in the next generation of immunotherapy. View Full-Text
Keywords: Immunotherapy; PD-1 (Programmed cell death protein 1); PD-L1 (Programmed death-ligand 1); monoclonal antibodies (mAbs) Immunotherapy; PD-1 (Programmed cell death protein 1); PD-L1 (Programmed death-ligand 1); monoclonal antibodies (mAbs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, Y.; Li, F.; Jiang, F.; Lv, X.; Zhang, R.; Lu, A.; Zhang, G. A Mini-Review for Cancer Immunotherapy: Molecular Understanding of PD-1/PD-L1 Pathway & Translational Blockade of Immune Checkpoints. Int. J. Mol. Sci. 2016, 17, 1151.

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